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Alternative catalytic residues in the active site of Esco acetyltransferases

Cohesin is a protein complex whose core subunits, Smc1, Smc3, Scc1, and SA1/SA2 form a ring-like structure encircling the DNA. Cohesins play a key role in the expression, repair, and segregation of eukaryotic genomes. Following a catalytic mechanism that is insufficiently understood, Esco1 and Esco2...

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Detalles Bibliográficos
Autores principales: Ajam, Tahereh, De, Inessa, Petkau, Nikolai, Whelan, Gabriela, Pena, Vladimir, Eichele, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300003/
https://www.ncbi.nlm.nih.gov/pubmed/32555289
http://dx.doi.org/10.1038/s41598-020-66795-z