Inhibition of G protein-gated K(+) channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

Sinus node (SAN) dysfunction (SND) manifests as low heart rate (HR) and is often accompanied by atrial tachycardia or atrioventricular (AV) block. The only currently available therapy for chronic SND is the implantation of an electronic pacemaker. Because of the growing burden of SND in the populati...

Descripción completa

Detalles Bibliográficos
Autores principales: Bidaud, Isabelle, Chong, Antony Chung You, Carcouet, Agnes, Waard, Stephan De, Charpentier, Flavien, Ronjat, Michel, Waard, Michel De, Isbrandt, Dirk, Wickman, Kevin, Vincent, Anne, Mangoni, Matteo E., Mesirca, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300035/
https://www.ncbi.nlm.nih.gov/pubmed/32555258
http://dx.doi.org/10.1038/s41598-020-66673-8

Ejemplares similares

Ejemplares similares