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GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation

Cells perceive and respond to the extracellular matrix via integrin receptors; their dysregulation has been implicated in inflammation and cancer metastasis. Here we show that a guanine nucleotide-exchange modulator of trimeric-GTPase Gαi, GIV (a.k.a Girdin), directly binds the integrin adaptor Kind...

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Detalles Bibliográficos
Autores principales:	Rohena, Cristina, Kalogriopoulos, Nicholas, Rajapakse, Navin, Roy, Suchismita, Lopez-Sanchez, Inmaculada, Ablack, Jailal, Sahoo, Debashis, Ghosh, Pradipta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300163/ https://www.ncbi.nlm.nih.gov/pubmed/32535026 http://dx.doi.org/10.1016/j.isci.2020.101209

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