Exploring the Impact of PARK2 Mutations on the Total and Mitochondrial Proteome of Human Skin Fibroblasts

Mutations in PARK2 gene are the most frequent cause of familial forms of Parkinson’s disease (PD). This gene encodes Parkin, an E3 ubiquitin ligase involved in several cellular mechanisms, including mitophagy. Parkin loss-of-function is responsible for the cellular accumulation of damaged mitochondr...

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Detalles Bibliográficos
Autores principales: Zilocchi, Mara, Colugnat, Ilaria, Lualdi, Marta, Meduri, Monica, Marini, Federica, Corasolla Carregari, Victor, Moutaoufik, Mohamed Taha, Phanse, Sadhna, Pieroni, Luisa, Babu, Mohan, Garavaglia, Barbara, Fasano, Mauro, Alberio, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300190/
https://www.ncbi.nlm.nih.gov/pubmed/32596240
http://dx.doi.org/10.3389/fcell.2020.00423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300190/
https://www.ncbi.nlm.nih.gov/pubmed/32596240
http://dx.doi.org/10.3389/fcell.2020.00423

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