Cargando…

Exploring the Impact of PARK2 Mutations on the Total and Mitochondrial Proteome of Human Skin Fibroblasts

Mutations in PARK2 gene are the most frequent cause of familial forms of Parkinson’s disease (PD). This gene encodes Parkin, an E3 ubiquitin ligase involved in several cellular mechanisms, including mitophagy. Parkin loss-of-function is responsible for the cellular accumulation of damaged mitochondr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zilocchi, Mara, Colugnat, Ilaria, Lualdi, Marta, Meduri, Monica, Marini, Federica, Corasolla Carregari, Victor, Moutaoufik, Mohamed Taha, Phanse, Sadhna, Pieroni, Luisa, Babu, Mohan, Garavaglia, Barbara, Fasano, Mauro, Alberio, Tiziana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300190/ https://www.ncbi.nlm.nih.gov/pubmed/32596240 http://dx.doi.org/10.3389/fcell.2020.00423

Ejemplares similares

Mitochondria under the spotlight: On the implications of mitochondrial dysfunction and its connectivity to neuropsychiatric disorders
por: Zilocchi, Mara, et al.
Publicado: (2020)

From fuzziness to precision medicine: on the rapidly evolving proteomics with implications in mitochondrial connectivity to rare human disease
por: Aly, Khaled A., et al.
Publicado: (2021)

Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli
por: Gagarinova, Alla, et al.
Publicado: (2022)

Exploring the Mitochondrial Degradome by the TAILS Proteomics Approach in a Cellular Model of Parkinson’s Disease
por: Lualdi, Marta, et al.
Publicado: (2019)

Exploring the HeLa Dark Mitochondrial Proteome
por: Marini, Federica, et al.
Publicado: (2020)

The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF
por: Jessulat, Matthew, et al.
Publicado: (2021)

Proteostasis and Proteotoxicity in the Network Medicine Era
por: Lualdi, Marta, et al.
Publicado: (2020)

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells
por: Alberio, Tiziana, et al.
Publicado: (2018)

Impact of Pharmacological Inhibition of Hydrogen Sulphide Production in the SOD1G93A-ALS Mouse Model
por: Spalloni, Alida, et al.
Publicado: (2019)

C9ORF72 Repeat Expansion Affects the Proteome of Primary Skin Fibroblasts in ALS
por: Lualdi, Marta, et al.
Publicado: (2021)

Current Insights on Neurodegeneration by the Italian Proteomics Community
por: Alberio, Tiziana, et al.
Publicado: (2022)

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis
por: Moutaoufik, Mohamed Taha, et al.
Publicado: (2019)

Proteomics of Muscle Microdialysates Identifies Potential Circulating Biomarkers in Facioscapulohumeral Muscular Dystrophy
por: Corasolla Carregari, Victor, et al.
Publicado: (2020)

A computational approach to rapidly design peptides that detect SARS-CoV-2 surface protein S
por: Hajikarimlou, Maryam, et al.
Publicado: (2022)

Towards a functional definition of the mitochondrial human proteome
por: Fasano, Mauro, et al.
Publicado: (2016)

Gene Set Enrichment Analysis of Interaction Networks Weighted by Node Centrality
por: Zito, Alessandra, et al.
Publicado: (2021)

Proteomics and Toxicity Analysis of Spinal-Cord Primary Cultures upon Hydrogen Sulfide Treatment
por: Greco, Viviana, et al.
Publicado: (2018)

The Role of Rab Proteins in Mitophagy: Insights into Neurodegenerative Diseases
por: Shafique, Adeena, et al.
Publicado: (2023)

A panoramic view of proteomics and multiomics in precision health
por: Zilocchi, Mara, et al.
Publicado: (2021)

HPiP: an R/Bioconductor package for predicting host–pathogen protein–protein interactions from protein sequences using ensemble machine learning approach
por: Rahmatbakhsh, Matineh, et al.
Publicado: (2022)

Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts
por: Zanellati, Maria C., et al.
Publicado: (2015)

A Correlation between 3′-UTR of OXA1 Gene and Yeast Mitochondrial Translation
por: Hajikarimlou, Maryam, et al.
Publicado: (2023)

Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease
por: Jakova, Elisabet, et al.
Publicado: (2022)

A Perspective on Extracellular Vesicles Proteomics
por: Rosa-Fernandes, Livia, et al.
Publicado: (2017)

Diagnostic Salivary Tests for SARS-CoV-2
por: Azzi, L., et al.
Publicado: (2020)

Experimental setup for the identification of mitochondrial protease substrates by shotgun and top-down proteomics
por: Di Pierro, Alice, et al.
Publicado: (2016)

Mitochondrial Targets for Pharmacological Intervention in Human Disease
por: Malty, Ramy H., et al.
Publicado: (2014)

HDL functionality is dependent on hepatocyte stress defense factors Nrf1 and Nrf2
por: Trites, Michael J., et al.
Publicado: (2023)

Systems biology analysis of the proteomic alterations induced by MPP(+), a Parkinson's disease-related mitochondrial toxin
por: Monti, Chiara, et al.
Publicado: (2015)

Looking at COVID-19 from a Systems Biology Perspective
por: Turilli, Emily Samuela, et al.
Publicado: (2022)

PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts
por: Amodio, Giuseppina, et al.
Publicado: (2019)

Biochemical, Pharmacological, and Structural Characterization of New Basic P L A (2) Bbil-TX from Bothriopsis bilineata Snake Venom
por: Corasolla Carregari, Victor, et al.
Publicado: (2013)

Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins
por: Turilli-Ghisolfi, Emily Samuela, et al.
Publicado: (2023)

The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing
por: Shallak, Mariam, et al.
Publicado: (2022)

A Lexicon of DNA Modifications: Their Roles in Embryo Development and the Germline
por: Zhu, Qifan, et al.
Publicado: (2018)

Keep in touch: a perspective on the mitochondrial social network and its implication in health and disease
por: Barabino, Silvia, et al.
Publicado: (2023)

MYC regulates metabolism through vesicular transfer of glycolytic kinases
por: Tsakaneli, Alexia, et al.
Publicado: (2021)

PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s Disease
por: Li, Wen, et al.
Publicado: (2021)

Embryo-derive TNF promotes decidualization via fibroblast activation
por: Chen, Si-Ting, et al.
Publicado: (2023)

Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains
por: Nascimento, Juliana Minardi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ols0rtdp71f9laie11c0dd7u9f