The underlying mechanisms of lorlatinib penetration across the blood‐brain barrier and the distribution characteristics of lorlatinib in the brain

OBJECTIVE: To clarify the distribution of lorlatinib in the brain and elucidate the molecular mechanisms of lorlatinib penetration across the blood‐brain barrier (BBB). METHODS: Cytological experiments were performed to investigate the growth inhibitory effect of lorlatinib on different cells (endot...

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Detalles Bibliográficos
Autores principales: Chen, Wei, Jin, Dujia, Shi, Yafei, Zhang, Yujun, Zhou, Haiyan, Li, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300403/
https://www.ncbi.nlm.nih.gov/pubmed/32347012
http://dx.doi.org/10.1002/cam4.3061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300403/
https://www.ncbi.nlm.nih.gov/pubmed/32347012
http://dx.doi.org/10.1002/cam4.3061

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