Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience

Coronavirus disease 2019 (COVID‐19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high‐risk cohort. The following is a short report on COVID‐19 in liver transplan...

Descripción completa

Detalles Bibliográficos
Autores principales: Verma, Anita, Khorsandi, Shirin Elizabeth, Dolcet, Annalisa, Prachalias, Andreas, Suddle, Abid, Heaton, Nigel, Jassem, Wayel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cirrhosis, Liver Failure and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300707/
https://www.ncbi.nlm.nih.gov/pubmed/32471013
http://dx.doi.org/10.1111/liv.14552
_version_ 1783547596572196864
author Verma, Anita
Khorsandi, Shirin Elizabeth
Dolcet, Annalisa
Prachalias, Andreas
Suddle, Abid
Heaton, Nigel
Jassem, Wayel
author_facet Verma, Anita
Khorsandi, Shirin Elizabeth
Dolcet, Annalisa
Prachalias, Andreas
Suddle, Abid
Heaton, Nigel
Jassem, Wayel
author_sort Verma, Anita
collection PubMed
description Coronavirus disease 2019 (COVID‐19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high‐risk cohort. The following is a short report on COVID‐19 in liver transplant recipients (n = 5) from a high volume UK liver transplant unit with a large follow‐up cohort (n = 4500). Based on this limited data, liver transplant recipients appear to have a low incidence of COVID‐19, with less severe symptoms than expected, when compared with the general population and other solid organ recipients. This possibly could be related to self‐isolation adherence and/or the ‘ideal’ level of immunosuppression that favourably modulates the immune response to COVID‐19.
format Online
Article
Text
id pubmed-7300707
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-73007072020-06-18 Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience Verma, Anita Khorsandi, Shirin Elizabeth Dolcet, Annalisa Prachalias, Andreas Suddle, Abid Heaton, Nigel Jassem, Wayel Liver Int Cirrhosis, Liver Failure and Transplantation Coronavirus disease 2019 (COVID‐19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high‐risk cohort. The following is a short report on COVID‐19 in liver transplant recipients (n = 5) from a high volume UK liver transplant unit with a large follow‐up cohort (n = 4500). Based on this limited data, liver transplant recipients appear to have a low incidence of COVID‐19, with less severe symptoms than expected, when compared with the general population and other solid organ recipients. This possibly could be related to self‐isolation adherence and/or the ‘ideal’ level of immunosuppression that favourably modulates the immune response to COVID‐19. John Wiley and Sons Inc. 2020-06-17 2020-08 /pmc/articles/PMC7300707/ /pubmed/32471013 http://dx.doi.org/10.1111/liv.14552 Text en © 2020 The Authors. Liver International published by John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cirrhosis, Liver Failure and Transplantation
Verma, Anita
Khorsandi, Shirin Elizabeth
Dolcet, Annalisa
Prachalias, Andreas
Suddle, Abid
Heaton, Nigel
Jassem, Wayel
Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience
title Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience
title_full Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience
title_fullStr Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience
title_full_unstemmed Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience
title_short Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience
title_sort low prevalence and disease severity of covid‐19 in post‐liver transplant recipients—a single centre experience
topic Cirrhosis, Liver Failure and Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300707/
https://www.ncbi.nlm.nih.gov/pubmed/32471013
http://dx.doi.org/10.1111/liv.14552
work_keys_str_mv AT vermaanita lowprevalenceanddiseaseseverityofcovid19inpostlivertransplantrecipientsasinglecentreexperience
AT khorsandishirinelizabeth lowprevalenceanddiseaseseverityofcovid19inpostlivertransplantrecipientsasinglecentreexperience
AT dolcetannalisa lowprevalenceanddiseaseseverityofcovid19inpostlivertransplantrecipientsasinglecentreexperience
AT prachaliasandreas lowprevalenceanddiseaseseverityofcovid19inpostlivertransplantrecipientsasinglecentreexperience
AT suddleabid lowprevalenceanddiseaseseverityofcovid19inpostlivertransplantrecipientsasinglecentreexperience
AT heatonnigel lowprevalenceanddiseaseseverityofcovid19inpostlivertransplantrecipientsasinglecentreexperience
AT jassemwayel lowprevalenceanddiseaseseverityofcovid19inpostlivertransplantrecipientsasinglecentreexperience

Ejemplares similares