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A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003
OBJECTIVES: To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in 2 Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. STUDY DESIGN: This is a cross-sectional study reviewin...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301144/ https://www.ncbi.nlm.nih.gov/pubmed/32565097 http://dx.doi.org/10.1016/j.jpeds.2020.06.041 |
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author | Xiong, Xiaoli Chua, Gilbert T. Chi, Shuiqing Kwan, Mike Yat Wah Sang Wong, Wilfred Hing Zhou, Aifen Shek, Chi Chiu Tung, Keith T.S. Qin, Huan Wong, Rosa S. Li, Xue Chen, Peng Li, Shuai Chui, Celine S. Tso, Winnie W.Y. Ho, Marco H.K. Wong, Ian C.K. Chan, Godfrey C.F. Lau, Yu Lung Wong, Kenneth K.Y. Chung, Patrick H.Y. Li, Hui Tam, Paul K.H. Tang, Shao-tao Ip, Patrick |
author_facet | Xiong, Xiaoli Chua, Gilbert T. Chi, Shuiqing Kwan, Mike Yat Wah Sang Wong, Wilfred Hing Zhou, Aifen Shek, Chi Chiu Tung, Keith T.S. Qin, Huan Wong, Rosa S. Li, Xue Chen, Peng Li, Shuai Chui, Celine S. Tso, Winnie W.Y. Ho, Marco H.K. Wong, Ian C.K. Chan, Godfrey C.F. Lau, Yu Lung Wong, Kenneth K.Y. Chung, Patrick H.Y. Li, Hui Tam, Paul K.H. Tang, Shao-tao Ip, Patrick |
author_sort | Xiong, Xiaoli |
collection | PubMed |
description | OBJECTIVES: To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in 2 Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. STUDY DESIGN: This is a cross-sectional study reviewing pediatric patients with SARS (n = 43) and COVID-19 (n = 244) who were admitted to the Princess Margaret Hospital in Hong Kong and Wuhan Children's Hospital in Wuhan, respectively. Demographics, hospital length of stay, and clinical and laboratory features were compared. RESULTS: Overall, 97.7% of patients with SARS and 85.2% of patients with COVID-19 had epidemiologic associations with known cases. Significantly more patients with SARS developed fever, chills, myalgia, malaise, coryza, sore throat, sputum production, nausea, headache, and dizziness than patients with COVID-19. No patients with SARS were asymptomatic at the time of admission, whereas 29.1% and 20.9% of patients with COVID-19 were asymptomatic on admission and throughout their hospital stay, respectively. More patients with SARS required oxygen supplementation than patients with COVID-19 (18.6 vs 4.7%; P = .004). Only 1.6% of patients with COVID-19 and 2.3% of patients with SARS required mechanical ventilation. Leukopenia (37.2% vs 18.6%; P = .008), lymphopenia (95.4% vs 32.6%; P < .01), and thrombocytopenia (41.9% vs 3.8%; P < .001) were significantly more common in patients with SARS than in patients with COVID-19. The duration between positive and negative nasopharyngeal aspirate and the length in hospital stay were similar in patients with COVID-19, regardless of whether they were asymptomatic or symptomatic, suggesting a similar duration of viral shedding. CONCLUSIONS: Children with COVID-19 were less symptomatic and had more favorable hematologic findings than children with SARS. |
format | Online Article Text |
id | pubmed-7301144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73011442020-06-18 A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003 Xiong, Xiaoli Chua, Gilbert T. Chi, Shuiqing Kwan, Mike Yat Wah Sang Wong, Wilfred Hing Zhou, Aifen Shek, Chi Chiu Tung, Keith T.S. Qin, Huan Wong, Rosa S. Li, Xue Chen, Peng Li, Shuai Chui, Celine S. Tso, Winnie W.Y. Ho, Marco H.K. Wong, Ian C.K. Chan, Godfrey C.F. Lau, Yu Lung Wong, Kenneth K.Y. Chung, Patrick H.Y. Li, Hui Tam, Paul K.H. Tang, Shao-tao Ip, Patrick J Pediatr Original Article OBJECTIVES: To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in 2 Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. STUDY DESIGN: This is a cross-sectional study reviewing pediatric patients with SARS (n = 43) and COVID-19 (n = 244) who were admitted to the Princess Margaret Hospital in Hong Kong and Wuhan Children's Hospital in Wuhan, respectively. Demographics, hospital length of stay, and clinical and laboratory features were compared. RESULTS: Overall, 97.7% of patients with SARS and 85.2% of patients with COVID-19 had epidemiologic associations with known cases. Significantly more patients with SARS developed fever, chills, myalgia, malaise, coryza, sore throat, sputum production, nausea, headache, and dizziness than patients with COVID-19. No patients with SARS were asymptomatic at the time of admission, whereas 29.1% and 20.9% of patients with COVID-19 were asymptomatic on admission and throughout their hospital stay, respectively. More patients with SARS required oxygen supplementation than patients with COVID-19 (18.6 vs 4.7%; P = .004). Only 1.6% of patients with COVID-19 and 2.3% of patients with SARS required mechanical ventilation. Leukopenia (37.2% vs 18.6%; P = .008), lymphopenia (95.4% vs 32.6%; P < .01), and thrombocytopenia (41.9% vs 3.8%; P < .001) were significantly more common in patients with SARS than in patients with COVID-19. The duration between positive and negative nasopharyngeal aspirate and the length in hospital stay were similar in patients with COVID-19, regardless of whether they were asymptomatic or symptomatic, suggesting a similar duration of viral shedding. CONCLUSIONS: Children with COVID-19 were less symptomatic and had more favorable hematologic findings than children with SARS. Elsevier Inc. 2020-09 2020-06-18 /pmc/articles/PMC7301144/ /pubmed/32565097 http://dx.doi.org/10.1016/j.jpeds.2020.06.041 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Xiong, Xiaoli Chua, Gilbert T. Chi, Shuiqing Kwan, Mike Yat Wah Sang Wong, Wilfred Hing Zhou, Aifen Shek, Chi Chiu Tung, Keith T.S. Qin, Huan Wong, Rosa S. Li, Xue Chen, Peng Li, Shuai Chui, Celine S. Tso, Winnie W.Y. Ho, Marco H.K. Wong, Ian C.K. Chan, Godfrey C.F. Lau, Yu Lung Wong, Kenneth K.Y. Chung, Patrick H.Y. Li, Hui Tam, Paul K.H. Tang, Shao-tao Ip, Patrick A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003 |
title | A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003 |
title_full | A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003 |
title_fullStr | A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003 |
title_full_unstemmed | A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003 |
title_short | A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003 |
title_sort | comparison between chinese children infected with coronavirus disease-2019 and with severe acute respiratory syndrome 2003 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301144/ https://www.ncbi.nlm.nih.gov/pubmed/32565097 http://dx.doi.org/10.1016/j.jpeds.2020.06.041 |
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