Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization

The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif. Here we show that hp can bind different motifs with high specificity. We identify a PxxPxF motif that is nece...

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Detalles Bibliográficos
Autores principales: Örd, Mihkel, Puss, Kait Kaarel, Kivi, Rait, Möll, Kaidi, Ojala, Tuuliki, Borovko, Irina, Faustova, Ilona, Venta, Rainis, Valk, Ervin, Kõivomägi, Mardo, Loog, Mart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301157/
https://www.ncbi.nlm.nih.gov/pubmed/32553169
http://dx.doi.org/10.1016/j.celrep.2020.107757

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