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Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma
BACKGROUND: Primary open-angle glaucoma (POAG) is associated with systemic microvascular dysfunction including hemorrhages and other abnormalities of the nailfold capillary bed. This study aimed to verify the specificity of nailfold capillary hemorrhages and other abnormalities as risk factors for P...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301193/ https://www.ncbi.nlm.nih.gov/pubmed/32587763 http://dx.doi.org/10.1155/2020/8324319 |
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author | Pfahler, Nicholas M. Barry, Jordan L. Bielskus, Indre E. Kakouri, Agni Giovingo, Michael C. Volpe, Nicholas J. Knepper, Paul A. |
author_facet | Pfahler, Nicholas M. Barry, Jordan L. Bielskus, Indre E. Kakouri, Agni Giovingo, Michael C. Volpe, Nicholas J. Knepper, Paul A. |
author_sort | Pfahler, Nicholas M. |
collection | PubMed |
description | BACKGROUND: Primary open-angle glaucoma (POAG) is associated with systemic microvascular dysfunction including hemorrhages and other abnormalities of the nailfold capillary bed. This study aimed to verify the specificity of nailfold capillary hemorrhages and other abnormalities as risk factors for POAG. METHODS: Nailfold video capillaroscopy was performed using a JH-1004 capillaroscope on the fourth and fifth digits of the nondominant hand in control (n = 277), POAG (n = 206), OHT (n = 57), and SG (n = 29) subjects. The number of hemorrhages, dilated capillaries >50 µm, and avascular zones ≥200 µm were counted and adjusted to counts per 100 capillaries. Descriptive analyses as well as univariate- and multivariable-adjusted logistic regression were performed comparing all groups with controls and POAG with OHT and SG. Subanalyses were conducted in POAG patients examining the association between nailfold capillary outcomes and previous glaucoma surgery, successful IOP control, or disease severity. RESULTS: All nailfold capillary outcomes were significantly increased in POAG, no outcomes were increased in SG, and only hemorrhages were mildly increased in OHT. Hemorrhages were significantly more frequent in POAG compared with both OHT (P < 0.0001) and SG (P=0.001). There were significant trends between higher numbers of hemorrhages and POAG compared with controls, OHT, and SG, with odds ratios of 18.3 (8.5–39.4), 9.1 (1.9–13.4), and 11.8 (1.7–7.3), respectively, for the presence of two or more hemorrhages per 100 capillaries. Hemorrhages were not significantly associated with previous glaucoma surgery, successful postoperative IOP control, or disease severity in POAG. CONCLUSIONS: These findings suggest that systemic microvascular dysfunction is frequent in POAG and occurs early in the disease process. The high specificity of nailfold hemorrhages makes them viable clinical risk factors for POAG. |
format | Online Article Text |
id | pubmed-7301193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73011932020-06-24 Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma Pfahler, Nicholas M. Barry, Jordan L. Bielskus, Indre E. Kakouri, Agni Giovingo, Michael C. Volpe, Nicholas J. Knepper, Paul A. J Ophthalmol Research Article BACKGROUND: Primary open-angle glaucoma (POAG) is associated with systemic microvascular dysfunction including hemorrhages and other abnormalities of the nailfold capillary bed. This study aimed to verify the specificity of nailfold capillary hemorrhages and other abnormalities as risk factors for POAG. METHODS: Nailfold video capillaroscopy was performed using a JH-1004 capillaroscope on the fourth and fifth digits of the nondominant hand in control (n = 277), POAG (n = 206), OHT (n = 57), and SG (n = 29) subjects. The number of hemorrhages, dilated capillaries >50 µm, and avascular zones ≥200 µm were counted and adjusted to counts per 100 capillaries. Descriptive analyses as well as univariate- and multivariable-adjusted logistic regression were performed comparing all groups with controls and POAG with OHT and SG. Subanalyses were conducted in POAG patients examining the association between nailfold capillary outcomes and previous glaucoma surgery, successful IOP control, or disease severity. RESULTS: All nailfold capillary outcomes were significantly increased in POAG, no outcomes were increased in SG, and only hemorrhages were mildly increased in OHT. Hemorrhages were significantly more frequent in POAG compared with both OHT (P < 0.0001) and SG (P=0.001). There were significant trends between higher numbers of hemorrhages and POAG compared with controls, OHT, and SG, with odds ratios of 18.3 (8.5–39.4), 9.1 (1.9–13.4), and 11.8 (1.7–7.3), respectively, for the presence of two or more hemorrhages per 100 capillaries. Hemorrhages were not significantly associated with previous glaucoma surgery, successful postoperative IOP control, or disease severity in POAG. CONCLUSIONS: These findings suggest that systemic microvascular dysfunction is frequent in POAG and occurs early in the disease process. The high specificity of nailfold hemorrhages makes them viable clinical risk factors for POAG. Hindawi 2020-06-08 /pmc/articles/PMC7301193/ /pubmed/32587763 http://dx.doi.org/10.1155/2020/8324319 Text en Copyright © 2020 Nicholas M. Pfahler et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pfahler, Nicholas M. Barry, Jordan L. Bielskus, Indre E. Kakouri, Agni Giovingo, Michael C. Volpe, Nicholas J. Knepper, Paul A. Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma |
title | Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma |
title_full | Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma |
title_fullStr | Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma |
title_full_unstemmed | Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma |
title_short | Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma |
title_sort | nailfold capillary hemorrhages: microvascular risk factors for primary open-angle glaucoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301193/ https://www.ncbi.nlm.nih.gov/pubmed/32587763 http://dx.doi.org/10.1155/2020/8324319 |
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