Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short‐lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We...

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Detalles Bibliográficos
Autores principales: Kelmer Sacramento, Erika, Kirkpatrick, Joanna M, Mazzetto, Mariateresa, Baumgart, Mario, Bartolome, Aleksandar, Di Sanzo, Simone, Caterino, Cinzia, Sanguanini, Michele, Papaevgeniou, Nikoletta, Lefaki, Maria, Childs, Dorothee, Bagnoli, Sara, Terzibasi Tozzini, Eva, Di Fraia, Domenico, Romanov, Natalie, Sudmant, Peter H, Huber, Wolfgang, Chondrogianni, Niki, Vendruscolo, Michele, Cellerino, Alessandro, Ori, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301280/
https://www.ncbi.nlm.nih.gov/pubmed/32558274
http://dx.doi.org/10.15252/msb.20209596

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