The unique characteristics of COVID-19 coagulopathy

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing incr...

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Autores principales: Iba, Toshiaki, Levy, Jerrold H., Connors, Jean Marie, Warkentin, Theodore E., Thachil, Jecko, Levi, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301352/
https://www.ncbi.nlm.nih.gov/pubmed/32552865
http://dx.doi.org/10.1186/s13054-020-03077-0
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author Iba, Toshiaki
Levy, Jerrold H.
Connors, Jean Marie
Warkentin, Theodore E.
Thachil, Jecko
Levi, Marcel
author_facet Iba, Toshiaki
Levy, Jerrold H.
Connors, Jean Marie
Warkentin, Theodore E.
Thachil, Jecko
Levi, Marcel
author_sort Iba, Toshiaki
collection PubMed
description Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC.
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spelling pubmed-73013522020-06-18 The unique characteristics of COVID-19 coagulopathy Iba, Toshiaki Levy, Jerrold H. Connors, Jean Marie Warkentin, Theodore E. Thachil, Jecko Levi, Marcel Crit Care Review Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC. BioMed Central 2020-06-18 /pmc/articles/PMC7301352/ /pubmed/32552865 http://dx.doi.org/10.1186/s13054-020-03077-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Iba, Toshiaki
Levy, Jerrold H.
Connors, Jean Marie
Warkentin, Theodore E.
Thachil, Jecko
Levi, Marcel
The unique characteristics of COVID-19 coagulopathy
title The unique characteristics of COVID-19 coagulopathy
title_full The unique characteristics of COVID-19 coagulopathy
title_fullStr The unique characteristics of COVID-19 coagulopathy
title_full_unstemmed The unique characteristics of COVID-19 coagulopathy
title_short The unique characteristics of COVID-19 coagulopathy
title_sort unique characteristics of covid-19 coagulopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301352/
https://www.ncbi.nlm.nih.gov/pubmed/32552865
http://dx.doi.org/10.1186/s13054-020-03077-0
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