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Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators?
BACKGROUND: Daily changes in ambient air pollution have been associated with cardiac morbidity and mortality. Precipitating a cardiac arrhythmia in susceptible individuals may be one mechanism. We investigated the influence of daily changes in air pollution in the Province of Ontario, Canada on the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301471/ https://www.ncbi.nlm.nih.gov/pubmed/32552837 http://dx.doi.org/10.1186/s12940-020-00622-w |
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author | Dales, Robert Lee, Douglas S. Wang, Xuesong Cakmak, Sabit Szyszkowicz, Mieczyslaw Shutt, Robin Birnie, David |
author_facet | Dales, Robert Lee, Douglas S. Wang, Xuesong Cakmak, Sabit Szyszkowicz, Mieczyslaw Shutt, Robin Birnie, David |
author_sort | Dales, Robert |
collection | PubMed |
description | BACKGROUND: Daily changes in ambient air pollution have been associated with cardiac morbidity and mortality. Precipitating a cardiac arrhythmia in susceptible individuals may be one mechanism. We investigated the influence of daily changes in air pollution in the Province of Ontario, Canada on the frequency of discharges from implantable cardio defibrillators (ICDs) which occur in response to potentially life threatening arrhythmias. METHODS: Using a case- crossover design, we compared ambient air pollution concentrations on the day of an ICD discharge to other days in the same month and year in 1952 patients. We adjusted for weather, lagged the exposure data from 0 to 3 days, and stratified the results by several patient-related characteristics. RESULTS: Median (interquartile range) for ozone (O(3)), fine particulate matter (PM(2.5)), sulphur dioxide (SO(2)) and nitrogen dioxide (NO(2)) were 26.0 ppb (19.4, 33.0), 6.6 μg/m(3) (4.3, 10.6), 1.00 ppb (0.4,2.1), 10.0 ppb (6.0,15.3) respectively. Unlagged odds ratios (95%) for an ICD discharge associated with an interquartile range increase in pollutant were 0.97 (0.86, 1.09) for O(3), 0.99 (0.92, 1.06) for PM(2.5), 0.97 (0.91, 1.03) for SO(2), and 1.00 (0.89, 1.12) for NO(2). CONCLUSION: We found no evidence that the concentrations of ambient air pollution observed in our study were a risk factor for potentially fatal cardiac arrhythmias in patients with ICDs. |
format | Online Article Text |
id | pubmed-7301471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73014712020-06-18 Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? Dales, Robert Lee, Douglas S. Wang, Xuesong Cakmak, Sabit Szyszkowicz, Mieczyslaw Shutt, Robin Birnie, David Environ Health Research BACKGROUND: Daily changes in ambient air pollution have been associated with cardiac morbidity and mortality. Precipitating a cardiac arrhythmia in susceptible individuals may be one mechanism. We investigated the influence of daily changes in air pollution in the Province of Ontario, Canada on the frequency of discharges from implantable cardio defibrillators (ICDs) which occur in response to potentially life threatening arrhythmias. METHODS: Using a case- crossover design, we compared ambient air pollution concentrations on the day of an ICD discharge to other days in the same month and year in 1952 patients. We adjusted for weather, lagged the exposure data from 0 to 3 days, and stratified the results by several patient-related characteristics. RESULTS: Median (interquartile range) for ozone (O(3)), fine particulate matter (PM(2.5)), sulphur dioxide (SO(2)) and nitrogen dioxide (NO(2)) were 26.0 ppb (19.4, 33.0), 6.6 μg/m(3) (4.3, 10.6), 1.00 ppb (0.4,2.1), 10.0 ppb (6.0,15.3) respectively. Unlagged odds ratios (95%) for an ICD discharge associated with an interquartile range increase in pollutant were 0.97 (0.86, 1.09) for O(3), 0.99 (0.92, 1.06) for PM(2.5), 0.97 (0.91, 1.03) for SO(2), and 1.00 (0.89, 1.12) for NO(2). CONCLUSION: We found no evidence that the concentrations of ambient air pollution observed in our study were a risk factor for potentially fatal cardiac arrhythmias in patients with ICDs. BioMed Central 2020-06-18 /pmc/articles/PMC7301471/ /pubmed/32552837 http://dx.doi.org/10.1186/s12940-020-00622-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Dales, Robert Lee, Douglas S. Wang, Xuesong Cakmak, Sabit Szyszkowicz, Mieczyslaw Shutt, Robin Birnie, David Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? |
title | Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? |
title_full | Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? |
title_fullStr | Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? |
title_full_unstemmed | Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? |
title_short | Do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? |
title_sort | do acute changes in ambient air pollution increase the risk of potentially fatal cardiac arrhythmias in patients with implantable cardioverter defibrillators? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301471/ https://www.ncbi.nlm.nih.gov/pubmed/32552837 http://dx.doi.org/10.1186/s12940-020-00622-w |
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