Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

BACKGROUND: In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guanine nucleotide exchange factor (GEF) for the Rab5 small GTPase family and has b...

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Detalles Bibliográficos
Autores principales: Shen, Ruinan, Zhao, Xiaobei, He, Lu, Ding, Yongbo, Xu, Wei, Lin, Suzhen, Fang, Savannah, Yang, Wanlin, Sung, Kijung, Spencer, Brian, Rissman, Robert A., Lei, Ming, Ding, Jianqing, Wu, Chengbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301499/
https://www.ncbi.nlm.nih.gov/pubmed/32552912
http://dx.doi.org/10.1186/s40035-020-00206-1

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