The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China

A prevalent PEDV strain, designated FJLY06, was isolated from Fujian, China. The four of structural genes sequences of PEDV obtained were analyzed to determine their phylogenetic relationships and homology respectively, revealing that FJLY06 was highly homologous to virulent PEDV strains. The four s...

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Autores principales: Dong, Bo, Dai, Ailing, Li, Xiaohua, Yang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301531/
https://www.ncbi.nlm.nih.gov/pubmed/32552768
http://dx.doi.org/10.1186/s12985-020-01345-7
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author Dong, Bo
Dai, Ailing
Li, Xiaohua
Yang, Xiaoyan
author_facet Dong, Bo
Dai, Ailing
Li, Xiaohua
Yang, Xiaoyan
author_sort Dong, Bo
collection PubMed
description A prevalent PEDV strain, designated FJLY06, was isolated from Fujian, China. The four of structural genes sequences of PEDV obtained were analyzed to determine their phylogenetic relationships and homology respectively, revealing that FJLY06 was highly homologous to virulent PEDV strains. The four structural genes all differed genetically from the vaccine strain CV777. The sequence alignment results further showed that N, M and E genes of Chinese PEDV strains is highly conserved. Compared with the vaccine strain CV777, 8 mutations were detected in COE of FJLY06 S gene. The recombination analysis revealed FJLY06 is similar to other pandemic strains in China with a variant S gene, and maybe a reason for recent vaccination failures.
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spelling pubmed-73015312020-06-18 The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China Dong, Bo Dai, Ailing Li, Xiaohua Yang, Xiaoyan Virol J Short Report A prevalent PEDV strain, designated FJLY06, was isolated from Fujian, China. The four of structural genes sequences of PEDV obtained were analyzed to determine their phylogenetic relationships and homology respectively, revealing that FJLY06 was highly homologous to virulent PEDV strains. The four structural genes all differed genetically from the vaccine strain CV777. The sequence alignment results further showed that N, M and E genes of Chinese PEDV strains is highly conserved. Compared with the vaccine strain CV777, 8 mutations were detected in COE of FJLY06 S gene. The recombination analysis revealed FJLY06 is similar to other pandemic strains in China with a variant S gene, and maybe a reason for recent vaccination failures. BioMed Central 2020-06-18 /pmc/articles/PMC7301531/ /pubmed/32552768 http://dx.doi.org/10.1186/s12985-020-01345-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Dong, Bo
Dai, Ailing
Li, Xiaohua
Yang, Xiaoyan
The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China
title The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China
title_full The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China
title_fullStr The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China
title_full_unstemmed The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China
title_short The four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in Fujian, China
title_sort four of structural genes sequences of a porcine epidemic diarrhea virus from domestic piglet in fujian, china
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301531/
https://www.ncbi.nlm.nih.gov/pubmed/32552768
http://dx.doi.org/10.1186/s12985-020-01345-7
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