Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol

[Image: see text] Malabaricol is a unique plant natural product, 3-keto tricarbocyclic triterpenoid, isolated from Ailanthus malabarica. Malabaricol underwent reaction with aromatic aldehydes under alkaline conditions to form 2-arylidene analogs. Indoles and pyrazine ring system fused to the 2,3-pos...

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Autores principales: Bommakanti, S. Srividya, Kundeti, Lakshmi Srinivasa Rao, Saddanapu, Venkateshwarlu, Nagaiah, Kommu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301604/
https://www.ncbi.nlm.nih.gov/pubmed/32566873
http://dx.doi.org/10.1021/acsomega.0c01525
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author Bommakanti, S. Srividya
Kundeti, Lakshmi Srinivasa Rao
Saddanapu, Venkateshwarlu
Nagaiah, Kommu
author_facet Bommakanti, S. Srividya
Kundeti, Lakshmi Srinivasa Rao
Saddanapu, Venkateshwarlu
Nagaiah, Kommu
author_sort Bommakanti, S. Srividya
collection PubMed
description [Image: see text] Malabaricol is a unique plant natural product, 3-keto tricarbocyclic triterpenoid, isolated from Ailanthus malabarica. Malabaricol underwent reaction with aromatic aldehydes under alkaline conditions to form 2-arylidene analogs. Indoles and pyrazine ring system fused to the 2,3-position of malabaricol were synthesized. In this ring system of tricarbocyclic triterpenoid, the conformation is such that there is no steric hindrance due to C(4) and C(10) axial methyl groups and other skeletons. Malabaricol and its synthetic analogues show cytotoxic activity toward lung cancer, which was compared to that of standard doxorubicin.
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spelling pubmed-73016042020-06-19 Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol Bommakanti, S. Srividya Kundeti, Lakshmi Srinivasa Rao Saddanapu, Venkateshwarlu Nagaiah, Kommu ACS Omega [Image: see text] Malabaricol is a unique plant natural product, 3-keto tricarbocyclic triterpenoid, isolated from Ailanthus malabarica. Malabaricol underwent reaction with aromatic aldehydes under alkaline conditions to form 2-arylidene analogs. Indoles and pyrazine ring system fused to the 2,3-position of malabaricol were synthesized. In this ring system of tricarbocyclic triterpenoid, the conformation is such that there is no steric hindrance due to C(4) and C(10) axial methyl groups and other skeletons. Malabaricol and its synthetic analogues show cytotoxic activity toward lung cancer, which was compared to that of standard doxorubicin. American Chemical Society 2020-06-01 /pmc/articles/PMC7301604/ /pubmed/32566873 http://dx.doi.org/10.1021/acsomega.0c01525 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Bommakanti, S. Srividya
Kundeti, Lakshmi Srinivasa Rao
Saddanapu, Venkateshwarlu
Nagaiah, Kommu
Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol
title Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol
title_full Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol
title_fullStr Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol
title_full_unstemmed Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol
title_short Synthesis and Cytotoxicity on Human Lung Cancer Cell Lines of 2-Arylidene and Related Analogues of Malabaricol
title_sort synthesis and cytotoxicity on human lung cancer cell lines of 2-arylidene and related analogues of malabaricol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301604/
https://www.ncbi.nlm.nih.gov/pubmed/32566873
http://dx.doi.org/10.1021/acsomega.0c01525
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