The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications

The renin–angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use of drugs that target this system, the RAS has...

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Autor principal: Diamond, Betty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301648/
https://www.ncbi.nlm.nih.gov/pubmed/32556101
http://dx.doi.org/10.1084/jem.20201000
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author Diamond, Betty
author_facet Diamond, Betty
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description The renin–angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use of drugs that target this system, the RAS has not been explored fully as a druggable target. The abbreviated description of the RAS suggests that its dysregulation may be at the center of COVID-19.
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spelling pubmed-73016482020-06-23 The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications Diamond, Betty J Exp Med Viewpoint The renin–angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use of drugs that target this system, the RAS has not been explored fully as a druggable target. The abbreviated description of the RAS suggests that its dysregulation may be at the center of COVID-19. Rockefeller University Press 2020-06-18 /pmc/articles/PMC7301648/ /pubmed/32556101 http://dx.doi.org/10.1084/jem.20201000 Text en © 2020 Diamond http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Viewpoint
Diamond, Betty
The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications
title The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications
title_full The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications
title_fullStr The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications
title_full_unstemmed The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications
title_short The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications
title_sort renin–angiotensin system: an integrated view of lung disease and coagulopathy in covid-19 and therapeutic implications
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301648/
https://www.ncbi.nlm.nih.gov/pubmed/32556101
http://dx.doi.org/10.1084/jem.20201000
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