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Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
Memantine, as an antagonist of α7-nAChR and NMDA receptors, may decrease ACE2 receptor expression and reduce oxidative stress and inflammation. Hence, memantine may potentially reduce SARS-CoV-2 virulence. https://bit.ly/2AZHiVg
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Respiratory Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301831/ https://www.ncbi.nlm.nih.gov/pubmed/32554535 http://dx.doi.org/10.1183/13993003.01610-2020 |
| Sumario: | Memantine, as an antagonist of α7-nAChR and NMDA receptors, may decrease ACE2 receptor expression and reduce oxidative stress and inflammation. Hence, memantine may potentially reduce SARS-CoV-2 virulence. https://bit.ly/2AZHiVg |
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