Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond

Memantine, as an antagonist of α7-nAChR and NMDA receptors, may decrease ACE2 receptor expression and reduce oxidative stress and inflammation. Hence, memantine may potentially reduce SARS-CoV-2 virulence. https://bit.ly/2AZHiVg

Detalles Bibliográficos
Autores principales: Hasanagic, Senad, Serdarevic, Fadila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Agora
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301831/
https://www.ncbi.nlm.nih.gov/pubmed/32554535
http://dx.doi.org/10.1183/13993003.01610-2020
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author Hasanagic, Senad
Serdarevic, Fadila
author_facet Hasanagic, Senad
Serdarevic, Fadila
author_sort Hasanagic, Senad
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description Memantine, as an antagonist of α7-nAChR and NMDA receptors, may decrease ACE2 receptor expression and reduce oxidative stress and inflammation. Hence, memantine may potentially reduce SARS-CoV-2 virulence. https://bit.ly/2AZHiVg
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spelling pubmed-73018312020-06-23 Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond Hasanagic, Senad Serdarevic, Fadila Eur Respir J Agora Memantine, as an antagonist of α7-nAChR and NMDA receptors, may decrease ACE2 receptor expression and reduce oxidative stress and inflammation. Hence, memantine may potentially reduce SARS-CoV-2 virulence. https://bit.ly/2AZHiVg European Respiratory Society 2020-08-13 /pmc/articles/PMC7301831/ /pubmed/32554535 http://dx.doi.org/10.1183/13993003.01610-2020 Text en Copyright ©ERS 2020. http://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Agora
Hasanagic, Senad
Serdarevic, Fadila
Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
title Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
title_full Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
title_fullStr Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
title_full_unstemmed Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
title_short Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
title_sort potential role of memantine in the prevention and treatment of covid-19: its antagonism of nicotinic acetylcholine receptors and beyond
topic Agora
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301831/
https://www.ncbi.nlm.nih.gov/pubmed/32554535
http://dx.doi.org/10.1183/13993003.01610-2020
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