Cargando…

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosenke, Kyle, Jarvis, Michael A., Feldmann, Friederike, Schwarz, Benjamin, Okumura, Atsushi, Lovaglio, Jamie, Saturday, Greg, Hanley, Patrick W., Meade-White, Kimberly, Williamson, Brandi N., Hansen, Frederick, Perez-Perez, Lizette, Leventhal, Shanna, Tang-Huau, Tsing-Lee, Nason, Martha, Callison, Julie, Haddock, Elaine, Scott, Dana, Sewell, Graham, Bosio, Catharine M., Hawman, David, de Wit, Emmie, Feldmann, Heinz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301902/ https://www.ncbi.nlm.nih.gov/pubmed/32577633 http://dx.doi.org/10.1101/2020.06.10.145144

Ejemplares similares

Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models
por: Rosenke, Kyle, et al.
Publicado: (2020)

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
por: Rosenke, Kyle, et al.
Publicado: (2020)

Development of a nonhuman primate model for mammalian bornavirus infection
por: Schlottau, Kore, et al.
Publicado: (2022)

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
por: Rosenke, Kyle, et al.
Publicado: (2021)

Three-Week Old Pigs Are Not Susceptible to Productive Infection with SARS-COV-2
por: Haddock, Elaine, et al.
Publicado: (2022)

UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates
por: Rosenke, Kyle, et al.
Publicado: (2021)

Mastomys natalensis Has a Cellular Immune Response Profile Distinct from Laboratory Mice
por: Tang-Huau, Tsing-Lee, et al.
Publicado: (2021)

T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice
por: Hawman, David W., et al.
Publicado: (2021)

Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques
por: Rosenke, Kyle, et al.
Publicado: (2023)

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques
por: Rosenke, Kyle, et al.
Publicado: (2022)

Single-dose VSV-based vaccine protects against Kyasanur Forest disease in nonhuman primates
por: Bhatia, Bharti, et al.
Publicado: (2023)

Domestic Pig Unlikely Reservoir for MERS-CoV
por: de Wit, Emmie, et al.
Publicado: (2017)

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus
por: Hawman, David W, et al.
Publicado: (2021)

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates
por: Rosenke, K., et al.
Publicado: (2021)

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
por: Hassan, Ahmed O., et al.
Publicado: (2021)

A Look into Bunyavirales Genomes: Functions of Non-Structural (NS) Proteins
por: Leventhal, Shanna S., et al.
Publicado: (2021)

Identifying Early Target Cells of Nipah Virus Infection in Syrian Hamsters
por: Baseler, Laura, et al.
Publicado: (2016)

Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2
por: Munster, Vincent J., et al.
Publicado: (2020)

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2
por: Munster, Vincent J., et al.
Publicado: (2020)

Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2
por: Williamson, Brandi N., et al.
Publicado: (2022)

Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate model
por: de Wit, Emmie, et al.
Publicado: (2022)

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection
por: Rosenke, Kyle, et al.
Publicado: (2020)

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection
por: Rosenke, Kyle, et al.
Publicado: (2020)

CD8(+) T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice
por: Rao, Deepashri, et al.
Publicado: (2023)

An Intramuscular DNA Vaccine for SARS-CoV-2 Decreases Viral Lung Load but Not Lung Pathology in Syrian Hamsters
por: Leventhal, Shanna S., et al.
Publicado: (2021)

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
por: van Doremalen, Neeltje, et al.
Publicado: (2022)

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
por: van Doremalen, Neeltje, et al.
Publicado: (2022)

Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge
por: Leventhal, Shanna S., et al.
Publicado: (2022)

Single low-dose VSV-EBOV vaccination protects cynomolgus macaques from lethal Ebola challenge
por: Marzi, Andrea, et al.
Publicado: (2019)

Histopathologic Characterization of Experimental Peracute SARS-CoV-2 Infection in the Syrian Hamster
por: Clancy, Chad S., et al.
Publicado: (2023)

Ebola Virus IgG Seroprevalence in Southern Mali
por: Bane, Sidy, et al.
Publicado: (2021)

SARS-CoV-2 reinfection prevents acute respiratory disease in Syrian hamsters but not replication in the upper respiratory tract
por: Hansen, Frederick, et al.
Publicado: (2022)

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
por: Williamson, Brandi N., et al.
Publicado: (2020)

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
por: Williamson, Brandi N., et al.
Publicado: (2020)

Use of Favipiravir to Treat Lassa Virus Infection in Macaques
por: Rosenke, Kyle, et al.
Publicado: (2018)

Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease
por: Monath, Thomas P., et al.
Publicado: (2023)

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques
por: Hasenkrug, Kim J., et al.
Publicado: (2021)

Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques
por: Hasenkrug, Kim J., et al.
Publicado: (2021)

Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys
por: Speranza, Emily, et al.
Publicado: (2021)

Prophylactic efficacy of a human monoclonal antibody against MERS-CoV in the common marmoset
por: de Wit, Emmie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ftlmbfif5ouvpkgbo9rgbc951v