POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression

Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identified a zinc-finger protein, pogo transposable element with zin...

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Detalles Bibliográficos
Autores principales: Gudmundsdottir, Bjorg, Gudmundsson, Kristbjorn O., Klarmann, Kimberly D., Singh, Satyendra K., Sun, Lei, Singh, Shweta, Du, Yang, Coppola, Vincenzo, Stockwin, Luke, Nguyen, Nhu, Tessarollo, Lino, Thorsteinsson, Leifur, Sigurjonsson, Olafur E., Gudmundsson, Sveinn, Rafnar, Thorunn, Tisdale, John F., Keller, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301966/
https://www.ncbi.nlm.nih.gov/pubmed/29898395
http://dx.doi.org/10.1016/j.celrep.2018.05.043

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