Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Severe COVID-19 is rare in previously healthy individuals who are less than 50 years of age, affecting probably no more than 1 in 1,000 such infected individuals. We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV-...

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Autores principales: Zhang, Shen-Ying, Zhang, Qian, Casanova, Jean-Laurent, Su, Helen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302118/
https://www.ncbi.nlm.nih.gov/pubmed/32555547
http://dx.doi.org/10.1038/s41577-020-0373-7
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author Zhang, Shen-Ying
Zhang, Qian
Casanova, Jean-Laurent
Su, Helen C.
author_facet Zhang, Shen-Ying
Zhang, Qian
Casanova, Jean-Laurent
Su, Helen C.
author_sort Zhang, Shen-Ying
collection PubMed
description Severe COVID-19 is rare in previously healthy individuals who are less than 50 years of age, affecting probably no more than 1 in 1,000 such infected individuals. We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV-2.
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spelling pubmed-73021182020-06-18 Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity? Zhang, Shen-Ying Zhang, Qian Casanova, Jean-Laurent Su, Helen C. Nat Rev Immunol Comment Severe COVID-19 is rare in previously healthy individuals who are less than 50 years of age, affecting probably no more than 1 in 1,000 such infected individuals. We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV-2. Nature Publishing Group UK 2020-06-18 2020 /pmc/articles/PMC7302118/ /pubmed/32555547 http://dx.doi.org/10.1038/s41577-020-0373-7 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Zhang, Shen-Ying
Zhang, Qian
Casanova, Jean-Laurent
Su, Helen C.
Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?
title Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?
title_full Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?
title_fullStr Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?
title_full_unstemmed Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?
title_short Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?
title_sort severe covid-19 in the young and healthy: monogenic inborn errors of immunity?
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302118/
https://www.ncbi.nlm.nih.gov/pubmed/32555547
http://dx.doi.org/10.1038/s41577-020-0373-7
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