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Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study

BACKGROUND: Exposure to air pollution was reported to affect glucose metabolism, increasing the risk of diabetes mellitus. We conducted an epidemiological study on glucose metabolism and air pollution by exploring the levels of fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) with changes in a...

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Autores principales: Hwang, Myung-Jae, Kim, Jong-Hun, Koo, Youn-Seo, Yun, Hui-Young, Cheong, Hae-Kwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302244/
https://www.ncbi.nlm.nih.gov/pubmed/32552747
http://dx.doi.org/10.1186/s12940-020-00623-9
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author Hwang, Myung-Jae
Kim, Jong-Hun
Koo, Youn-Seo
Yun, Hui-Young
Cheong, Hae-Kwan
author_facet Hwang, Myung-Jae
Kim, Jong-Hun
Koo, Youn-Seo
Yun, Hui-Young
Cheong, Hae-Kwan
author_sort Hwang, Myung-Jae
collection PubMed
description BACKGROUND: Exposure to air pollution was reported to affect glucose metabolism, increasing the risk of diabetes mellitus. We conducted an epidemiological study on glucose metabolism and air pollution by exploring the levels of fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) with changes in ambient air quality, depending on the characteristics of the susceptible population. METHODS: We carried out a cross-sectional analysis of a nationally representative sample of 10,014 adults (4267 in male and 5747 in female) from the Korea National Health and Nutrition Examination Survey in 2012 and 2013 along with data from the Korean Air Quality Forecasting System. The analysis was performed using a generalized linear model stratified by sex, age, and presence of diabetes. We assessed the changes in FBG and HbA1c associated with exposures to particulate matter (PM(10)), fine particulate matter (PM(2.5)), and nitrogen dioxide (NO(2)) after controlling for confounders. RESULTS: There were 1110 participants with diabetes (557 in male and 553 in female). Overall, the FBG level increased by 7.83 mg/dL (95% confidence interval [CI]: 2.80–12.87) per interquartile range (IQR) increment of NO(2), 5.32 mg/dL (95% CI: 1.22–9.41) per IQR increment of PM(10) at a moving average of 0–6 days, and 4.69 mg/dL (95% CI: 0.48–8.91) per IQR increment of PM(2.5) at a moving average of 0–5 days. HbA1c increased by 0.57% (95% CI: 0.04–1.09) per IQR increment of PM(10) at a moving average of 0–60 days and 0.34% (95% CI: 0.04–0.63) per IQR increment of PM(2.5) at a moving average of 0–75 days. The change in FBG and HbA1c increased more in the diabetic group, especially in males aged 65 years or more. There was a strong association between elevation in diabetes-related parameters and exposure to air pollution. CONCLUSIONS: Our study provides scientific evidence supporting that short- and mid-term exposure to air pollution is associated with changes in biological markers related to diabetes. This finding suggests that the impact of air pollution should be reflected in chronic disease management when establishing local health care policies.
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spelling pubmed-73022442020-06-19 Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study Hwang, Myung-Jae Kim, Jong-Hun Koo, Youn-Seo Yun, Hui-Young Cheong, Hae-Kwan Environ Health Research BACKGROUND: Exposure to air pollution was reported to affect glucose metabolism, increasing the risk of diabetes mellitus. We conducted an epidemiological study on glucose metabolism and air pollution by exploring the levels of fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) with changes in ambient air quality, depending on the characteristics of the susceptible population. METHODS: We carried out a cross-sectional analysis of a nationally representative sample of 10,014 adults (4267 in male and 5747 in female) from the Korea National Health and Nutrition Examination Survey in 2012 and 2013 along with data from the Korean Air Quality Forecasting System. The analysis was performed using a generalized linear model stratified by sex, age, and presence of diabetes. We assessed the changes in FBG and HbA1c associated with exposures to particulate matter (PM(10)), fine particulate matter (PM(2.5)), and nitrogen dioxide (NO(2)) after controlling for confounders. RESULTS: There were 1110 participants with diabetes (557 in male and 553 in female). Overall, the FBG level increased by 7.83 mg/dL (95% confidence interval [CI]: 2.80–12.87) per interquartile range (IQR) increment of NO(2), 5.32 mg/dL (95% CI: 1.22–9.41) per IQR increment of PM(10) at a moving average of 0–6 days, and 4.69 mg/dL (95% CI: 0.48–8.91) per IQR increment of PM(2.5) at a moving average of 0–5 days. HbA1c increased by 0.57% (95% CI: 0.04–1.09) per IQR increment of PM(10) at a moving average of 0–60 days and 0.34% (95% CI: 0.04–0.63) per IQR increment of PM(2.5) at a moving average of 0–75 days. The change in FBG and HbA1c increased more in the diabetic group, especially in males aged 65 years or more. There was a strong association between elevation in diabetes-related parameters and exposure to air pollution. CONCLUSIONS: Our study provides scientific evidence supporting that short- and mid-term exposure to air pollution is associated with changes in biological markers related to diabetes. This finding suggests that the impact of air pollution should be reflected in chronic disease management when establishing local health care policies. BioMed Central 2020-06-17 /pmc/articles/PMC7302244/ /pubmed/32552747 http://dx.doi.org/10.1186/s12940-020-00623-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hwang, Myung-Jae
Kim, Jong-Hun
Koo, Youn-Seo
Yun, Hui-Young
Cheong, Hae-Kwan
Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study
title Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study
title_full Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study
title_fullStr Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study
title_full_unstemmed Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study
title_short Impacts of ambient air pollution on glucose metabolism in Korean adults: a Korea National Health and Nutrition Examination Survey study
title_sort impacts of ambient air pollution on glucose metabolism in korean adults: a korea national health and nutrition examination survey study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302244/
https://www.ncbi.nlm.nih.gov/pubmed/32552747
http://dx.doi.org/10.1186/s12940-020-00623-9
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