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Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation

We used multi-agent simulations to estimate the testing capacity required to find and isolate a number of infections sufficient to break the chain of transmission of SARS-CoV-2. Depending on the mitigation policies in place, a daily capacity between 0.7 to 3.6 tests per thousand was required to cont...

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Autores principales: Fiore, Vincenzo G., DeFelice, Nicholas, Glicksberg, Benjamin S., Perl, Ofer, Shuster, Anastasia, Kulkarni, Kaustubh, O’Brien, Madeline, Pisauro, M. Andrea, Chung, Dongil, Gu, Xiaosi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302294/
https://www.ncbi.nlm.nih.gov/pubmed/32577688
http://dx.doi.org/10.1101/2020.06.05.20123372
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author Fiore, Vincenzo G.
DeFelice, Nicholas
Glicksberg, Benjamin S.
Perl, Ofer
Shuster, Anastasia
Kulkarni, Kaustubh
O’Brien, Madeline
Pisauro, M. Andrea
Chung, Dongil
Gu, Xiaosi
author_facet Fiore, Vincenzo G.
DeFelice, Nicholas
Glicksberg, Benjamin S.
Perl, Ofer
Shuster, Anastasia
Kulkarni, Kaustubh
O’Brien, Madeline
Pisauro, M. Andrea
Chung, Dongil
Gu, Xiaosi
author_sort Fiore, Vincenzo G.
collection PubMed
description We used multi-agent simulations to estimate the testing capacity required to find and isolate a number of infections sufficient to break the chain of transmission of SARS-CoV-2. Depending on the mitigation policies in place, a daily capacity between 0.7 to 3.6 tests per thousand was required to contain the disease. However, if contact tracing and testing efficacy dropped below 60% (e.g. due to false negatives or reduced tracing capability), the number of infections kept growing exponentially, irrespective of any testing capacity. Under these conditions, the population’s geographical distribution and travel behaviour could inform sampling policies to aid a successful containment.
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spelling pubmed-73022942020-06-23 Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation Fiore, Vincenzo G. DeFelice, Nicholas Glicksberg, Benjamin S. Perl, Ofer Shuster, Anastasia Kulkarni, Kaustubh O’Brien, Madeline Pisauro, M. Andrea Chung, Dongil Gu, Xiaosi medRxiv Article We used multi-agent simulations to estimate the testing capacity required to find and isolate a number of infections sufficient to break the chain of transmission of SARS-CoV-2. Depending on the mitigation policies in place, a daily capacity between 0.7 to 3.6 tests per thousand was required to contain the disease. However, if contact tracing and testing efficacy dropped below 60% (e.g. due to false negatives or reduced tracing capability), the number of infections kept growing exponentially, irrespective of any testing capacity. Under these conditions, the population’s geographical distribution and travel behaviour could inform sampling policies to aid a successful containment. Cold Spring Harbor Laboratory 2020-06-07 /pmc/articles/PMC7302294/ /pubmed/32577688 http://dx.doi.org/10.1101/2020.06.05.20123372 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/It is made available under a CC-BY-NC-ND 4.0 International license (http://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Article
Fiore, Vincenzo G.
DeFelice, Nicholas
Glicksberg, Benjamin S.
Perl, Ofer
Shuster, Anastasia
Kulkarni, Kaustubh
O’Brien, Madeline
Pisauro, M. Andrea
Chung, Dongil
Gu, Xiaosi
Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
title Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
title_full Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
title_fullStr Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
title_full_unstemmed Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
title_short Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
title_sort containment of future waves of covid-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302294/
https://www.ncbi.nlm.nih.gov/pubmed/32577688
http://dx.doi.org/10.1101/2020.06.05.20123372
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