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PAC(1) receptor blockade reduces central nociceptive activity: new approach for primary headache?

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclinical evidence suggests that PACAP38 modulates trigeminal nociceptive activity mainly through PAC(1) receptors while clinical studies report that plasma concentrations of PACAP38 ar...

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Detalles Bibliográficos
Autores principales:	Hoffmann, Jan, Miller, Silke, Martins-Oliveira, Margarida, Akerman, Simon, Supronsinchai, Weera, Sun, Hong, Shi, Licheng, Wang, Judy, Zhu, Dawn, Lehto, Sonya, Liu, Hantao, Yin, Ruoyuan, Moyer, Bryan D., Xu, Cen, Goadsby, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302332/ https://www.ncbi.nlm.nih.gov/pubmed/32142016 http://dx.doi.org/10.1097/j.pain.0000000000001858

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