The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia

BACKGROUND: Mixed-lineage leukemia (MLL) gene rearrangements trigger aberrant epigenetic modification and gene expression in hematopoietic stem and progenitor cells, which generates one of the most aggressive subtypes of leukemia with an apex self-renewal. It remains a challenge to directly inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wen-Tao, Chen, Tian-Qi, Zeng, Zhan-Cheng, Pan, Qi, Huang, Wei, Han, Cai, Fang, Ke, Sun, Lin-Yu, Yang, Qian-Qian, Wang, Dan, Luo, Xue-Qun, Sun, Yu-Meng, Chen, Yue-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302350/
https://www.ncbi.nlm.nih.gov/pubmed/32552847
http://dx.doi.org/10.1186/s13045-020-00909-y

Ejemplares similares

Ejemplares similares