MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma

MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-relat...

Descripción completa

Detalles Bibliográficos
Autores principales: Otoukesh, Babak, Abbasi, Mehdi, Gorgani, Habib-o-Lah, Farahini, Hossein, Moghtadaei, Mehdi, Boddouhi, Bahram, Kaghazian, Peyman, Hosseinzadeh, Shayan, Alaee, Atefe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302353/
https://www.ncbi.nlm.nih.gov/pubmed/32565738
http://dx.doi.org/10.1186/s12935-020-01342-4
_version_ 1783547827962511360
author Otoukesh, Babak
Abbasi, Mehdi
Gorgani, Habib-o-Lah
Farahini, Hossein
Moghtadaei, Mehdi
Boddouhi, Bahram
Kaghazian, Peyman
Hosseinzadeh, Shayan
Alaee, Atefe
author_facet Otoukesh, Babak
Abbasi, Mehdi
Gorgani, Habib-o-Lah
Farahini, Hossein
Moghtadaei, Mehdi
Boddouhi, Bahram
Kaghazian, Peyman
Hosseinzadeh, Shayan
Alaee, Atefe
author_sort Otoukesh, Babak
collection PubMed
description MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.
format Online
Article
Text
id pubmed-7302353
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-73023532020-06-19 MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma Otoukesh, Babak Abbasi, Mehdi Gorgani, Habib-o-Lah Farahini, Hossein Moghtadaei, Mehdi Boddouhi, Bahram Kaghazian, Peyman Hosseinzadeh, Shayan Alaee, Atefe Cancer Cell Int Review MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted. BioMed Central 2020-06-17 /pmc/articles/PMC7302353/ /pubmed/32565738 http://dx.doi.org/10.1186/s12935-020-01342-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Otoukesh, Babak
Abbasi, Mehdi
Gorgani, Habib-o-Lah
Farahini, Hossein
Moghtadaei, Mehdi
Boddouhi, Bahram
Kaghazian, Peyman
Hosseinzadeh, Shayan
Alaee, Atefe
MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
title MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
title_full MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
title_fullStr MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
title_full_unstemmed MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
title_short MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
title_sort micrornas signatures, bioinformatics analysis of mirnas, mirna mimics and antagonists, and mirna therapeutics in osteosarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302353/
https://www.ncbi.nlm.nih.gov/pubmed/32565738
http://dx.doi.org/10.1186/s12935-020-01342-4
work_keys_str_mv AT otoukeshbabak micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT abbasimehdi micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT gorganihabibolah micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT farahinihossein micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT moghtadaeimehdi micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT boddouhibahram micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT kaghazianpeyman micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT hosseinzadehshayan micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma
AT alaeeatefe micrornassignaturesbioinformaticsanalysisofmirnasmirnamimicsandantagonistsandmirnatherapeuticsinosteosarcoma

Ejemplares similares