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Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)

The purpose of this study was to develop the Glasgow Antipsychotic Side effects Scale for Clozapine Japanese version (GASS-C-J) and examine its reliability to assess clozapine-related side effects. We developed the GASS-C-J using forward and backward translation. Semantic equivalence of the GASS-C-J...

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Autores principales: Kitagawa, Kohei, So, Ryuhei, Nomura, Nobuyuki, Mizuno, Yuya, Misawa, Fuminari, Kodama, Masafumi, Uchida, Hiroyuki, Mimura, Masaru, Takeuchi, Hiroyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302491/
https://www.ncbi.nlm.nih.gov/pubmed/32555706
http://dx.doi.org/10.1371/journal.pone.0234864
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author Kitagawa, Kohei
So, Ryuhei
Nomura, Nobuyuki
Mizuno, Yuya
Misawa, Fuminari
Kodama, Masafumi
Uchida, Hiroyuki
Mimura, Masaru
Takeuchi, Hiroyoshi
author_facet Kitagawa, Kohei
So, Ryuhei
Nomura, Nobuyuki
Mizuno, Yuya
Misawa, Fuminari
Kodama, Masafumi
Uchida, Hiroyuki
Mimura, Masaru
Takeuchi, Hiroyoshi
author_sort Kitagawa, Kohei
collection PubMed
description The purpose of this study was to develop the Glasgow Antipsychotic Side effects Scale for Clozapine Japanese version (GASS-C-J) and examine its reliability to assess clozapine-related side effects. We developed the GASS-C-J using forward and backward translation. Semantic equivalence of the GASS-C-J to the GASS-C was confirmed by the original author. We then administered the GASS-C-J twice to 109 patients on clozapine treatment at two psychiatric hospitals in Japan. We assessed the internal consistency and test-retest reliability of the GASS-C-J using Cronbach’s alpha and weighted kappa coefficient, respectively. We also examined if discrepancies in each GASS-C-J item score between the first and second rating were correlated with items of the Brief Evaluation of Psychosis Symptom Domains (BE-PSD). The Cronbach’s alpha coefficient of the GASS-C-J at the first and second rating was 0.78 (95% CI: 0.72 to 0.84) and 0.82 (95% CI: 0.76 to 0.88), respectively. The weighted kappa coefficient of individual and total GASS-C-J item scores ranged from 0.45 to 0.88. Some symptom domains were correlated with discrepancies in specific items of the GASS-C-J: psychotic symptoms and nausea/vomiting (r(s) = 0.27), thirst (r(s) = 0.31), and appetite/weight gain (r(s) = 0.27); disorganized thinking and urinary incontinence (r(s) = 0.26); depression/anxiety and myoclonus (r(s) = 0.25), hypersalivation (r(s) = -0.27), and blurred vision (r(s) = -0.22). These findings demonstrate that the GASS-C-J can be used in clinical and research settings as a reliable scale to assess clozapine-related side effects.
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spelling pubmed-73024912020-06-19 Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J) Kitagawa, Kohei So, Ryuhei Nomura, Nobuyuki Mizuno, Yuya Misawa, Fuminari Kodama, Masafumi Uchida, Hiroyuki Mimura, Masaru Takeuchi, Hiroyoshi PLoS One Research Article The purpose of this study was to develop the Glasgow Antipsychotic Side effects Scale for Clozapine Japanese version (GASS-C-J) and examine its reliability to assess clozapine-related side effects. We developed the GASS-C-J using forward and backward translation. Semantic equivalence of the GASS-C-J to the GASS-C was confirmed by the original author. We then administered the GASS-C-J twice to 109 patients on clozapine treatment at two psychiatric hospitals in Japan. We assessed the internal consistency and test-retest reliability of the GASS-C-J using Cronbach’s alpha and weighted kappa coefficient, respectively. We also examined if discrepancies in each GASS-C-J item score between the first and second rating were correlated with items of the Brief Evaluation of Psychosis Symptom Domains (BE-PSD). The Cronbach’s alpha coefficient of the GASS-C-J at the first and second rating was 0.78 (95% CI: 0.72 to 0.84) and 0.82 (95% CI: 0.76 to 0.88), respectively. The weighted kappa coefficient of individual and total GASS-C-J item scores ranged from 0.45 to 0.88. Some symptom domains were correlated with discrepancies in specific items of the GASS-C-J: psychotic symptoms and nausea/vomiting (r(s) = 0.27), thirst (r(s) = 0.31), and appetite/weight gain (r(s) = 0.27); disorganized thinking and urinary incontinence (r(s) = 0.26); depression/anxiety and myoclonus (r(s) = 0.25), hypersalivation (r(s) = -0.27), and blurred vision (r(s) = -0.22). These findings demonstrate that the GASS-C-J can be used in clinical and research settings as a reliable scale to assess clozapine-related side effects. Public Library of Science 2020-06-18 /pmc/articles/PMC7302491/ /pubmed/32555706 http://dx.doi.org/10.1371/journal.pone.0234864 Text en © 2020 Kitagawa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kitagawa, Kohei
So, Ryuhei
Nomura, Nobuyuki
Mizuno, Yuya
Misawa, Fuminari
Kodama, Masafumi
Uchida, Hiroyuki
Mimura, Masaru
Takeuchi, Hiroyoshi
Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)
title Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)
title_full Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)
title_fullStr Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)
title_full_unstemmed Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)
title_short Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)
title_sort reliability of the glasgow antipsychotic side-effects scale for clozapine japanese version (gass-c-j)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302491/
https://www.ncbi.nlm.nih.gov/pubmed/32555706
http://dx.doi.org/10.1371/journal.pone.0234864
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