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Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts kinesin KIF1A and KIF5C recruitment during egress, and alters the properties of microtubule-dependent transport in vitro

During infection of neurons by alphaherpesviruses including Pseudorabies virus (PRV) and Herpes simplex virus type 1 (HSV-1) viral nucleocapsids assemble in the cell nucleus, become enveloped in the cell body then traffic into and down axons to nerve termini for spread to adjacent epithelia. The vir...

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Detalles Bibliográficos
Autores principales: Diwaker, Drishya, Murray, John W., Barnes, Jenna, Wolkoff, Allan W., Wilson, Duncan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302734/
https://www.ncbi.nlm.nih.gov/pubmed/32511265
http://dx.doi.org/10.1371/journal.ppat.1008597