Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia

The emergence of multicellularity in Animalia is associated with increase in ROS and expansion of tRNA-isodecoders. tRNA expansion leads to misselection resulting in a critical error of L-Ala mischarged onto tRNA(Thr), which is proofread by Animalia-specific-tRNA Deacylase (ATD) in vitro. Here we sh...

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Detalles Bibliográficos
Autores principales: Kuncha, Santosh Kumar, Venkadasamy, Vinitha Lakshmi, Amudhan, Gurumoorthy, Dahate, Priyanka, Kola, Sankara Rao, Pottabathini, Sambhavi, Kruparani, Shobha P, Shekar, P Chandra, Sankaranarayanan, Rajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302879/
https://www.ncbi.nlm.nih.gov/pubmed/32463355
http://dx.doi.org/10.7554/eLife.58118

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