T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to induce nAbs, or together with a heterologous vira...

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Detalles Bibliográficos
Autores principales: Arunachalam, Prabhu S., Charles, Tysheena P., Joag, Vineet, Bollimpelli, Venkata S., Scott, Madeleine K. D., Wimmers, Florian, Burton, Samantha L., Labranche, Celia C., Petitdemange, Caroline, Gangadhara, Sailaja, Styles, Tiffany M., Quarnstrom, Clare F., Walter, Korey A., Ketas, Thomas J., Legere, Traci, Jagadeesh Reddy, Pradeep Babu, Kasturi, Sudhir Pai, Tsai, Anthony, Yeung, Bertrand Z., Gupta, Shakti, Tomai, Mark, Vasilakos, John, Shaw, George M., Kang, Chil-Yong, Moore, John P., Subramaniam, Shankar, Khatri, Purvesh, Montefiori, David, Kozlowski, Pamela A., Derdeyn, Cynthia A., Hunter, Eric, Masopust, David, Amara, Rama R., Pulendran, Bali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303014/
https://www.ncbi.nlm.nih.gov/pubmed/32393800
http://dx.doi.org/10.1038/s41591-020-0858-8

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