Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab

Bevacizumab has been used as an effective drug for ovarian cancer. However, serious adverse effects, such as gastrointestinal perforation, can occur. Spontaneous gastrointestinal perforation is an uncommon, yet life-threatening complication related to bevacizumab administration. We present the case...

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Autores principales: Karanikas, Michael, Kofina, Konstantinia, Potolidis, Dimitrios, Foutzitzi, Soultana, Deftereos, Savas, Effraemidou, Eleni, Lyratzopoulos, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303021/
https://www.ncbi.nlm.nih.gov/pubmed/32595926
http://dx.doi.org/10.1093/jscr/rjaa174
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author Karanikas, Michael
Kofina, Konstantinia
Potolidis, Dimitrios
Foutzitzi, Soultana
Deftereos, Savas
Effraemidou, Eleni
Lyratzopoulos, Nikolaos
author_facet Karanikas, Michael
Kofina, Konstantinia
Potolidis, Dimitrios
Foutzitzi, Soultana
Deftereos, Savas
Effraemidou, Eleni
Lyratzopoulos, Nikolaos
author_sort Karanikas, Michael
collection PubMed
description Bevacizumab has been used as an effective drug for ovarian cancer. However, serious adverse effects, such as gastrointestinal perforation, can occur. Spontaneous gastrointestinal perforation is an uncommon, yet life-threatening complication related to bevacizumab administration. We present the case of a 65-year-old Caucasian female who presented with acute abdomen 10 days after the first administration of bevacizumab for ovarian cancer treatment, and she was diagnosed intraoperatively with a massive duodenal perforation. Bowel perforation after bevacizumab administration is a serious and potentially lethal complication. Careful follow-up of the patients is necessary in order to detect any signs of this condition in time.
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spelling pubmed-73030212020-06-25 Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab Karanikas, Michael Kofina, Konstantinia Potolidis, Dimitrios Foutzitzi, Soultana Deftereos, Savas Effraemidou, Eleni Lyratzopoulos, Nikolaos J Surg Case Rep Case Report Bevacizumab has been used as an effective drug for ovarian cancer. However, serious adverse effects, such as gastrointestinal perforation, can occur. Spontaneous gastrointestinal perforation is an uncommon, yet life-threatening complication related to bevacizumab administration. We present the case of a 65-year-old Caucasian female who presented with acute abdomen 10 days after the first administration of bevacizumab for ovarian cancer treatment, and she was diagnosed intraoperatively with a massive duodenal perforation. Bowel perforation after bevacizumab administration is a serious and potentially lethal complication. Careful follow-up of the patients is necessary in order to detect any signs of this condition in time. Oxford University Press 2020-06-19 /pmc/articles/PMC7303021/ /pubmed/32595926 http://dx.doi.org/10.1093/jscr/rjaa174 Text en Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Karanikas, Michael
Kofina, Konstantinia
Potolidis, Dimitrios
Foutzitzi, Soultana
Deftereos, Savas
Effraemidou, Eleni
Lyratzopoulos, Nikolaos
Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab
title Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab
title_full Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab
title_fullStr Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab
title_full_unstemmed Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab
title_short Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab
title_sort spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303021/
https://www.ncbi.nlm.nih.gov/pubmed/32595926
http://dx.doi.org/10.1093/jscr/rjaa174
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