Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice

Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. Both compounds inhibit γ-aminobutyric acid type-A (GABA(A)) receptors with similar potency. However, TETS is approximately 100 × more...

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Detalles Bibliográficos
Autores principales: Pressly, Brandon, Vasylieva, Natalia, Barnych, Bogdan, Singh, Vikrant, Singh, Latika, Bruun, Donald A., Hwang, Sung Hee, Chen, Yi-Je, Fettinger, James C., Johnnides, Stephanie, Lein, Pamela J., Yang, Jun, Hammock, Bruce D., Wulff, Heike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303059/
https://www.ncbi.nlm.nih.gov/pubmed/32239239
http://dx.doi.org/10.1007/s00204-020-02728-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303059/
https://www.ncbi.nlm.nih.gov/pubmed/32239239
http://dx.doi.org/10.1007/s00204-020-02728-z

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