Ultrafine silicon dioxide nanoparticles cause lung epithelial cells apoptosis via oxidative stress-activated PI3K/Akt-mediated mitochondria- and endoplasmic reticulum stress-dependent signaling pathways

Silicon dioxide nanoparticles (SiO(2)NPs) are widely applied in industry, chemical, and cosmetics. SiO(2)NPs is known to induce pulmonary toxicity. In this study, we investigated the molecular mechanisms of SiO(2)NPs on pulmonary toxicity using a lung alveolar epithelial cell (L2) model. SiO(2)NPs,...

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Detalles Bibliográficos
Autores principales: Lee, Kuan-I, Su, Chin-Chuan, Fang, Kai-Min, Wu, Chin-Ching, Wu, Cheng-Tien, Chen, Ya-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303152/
https://www.ncbi.nlm.nih.gov/pubmed/32555254
http://dx.doi.org/10.1038/s41598-020-66644-z

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