Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns

Primary plasma cell leukemia (pPCL) is a rare and aggressive form of multiple myeloma (MM) that is characterized by the presence of ≥20% circulating plasma cells. Overall survival remains poor despite advances of anti-MM therapy. The disease biology as well as molecular mechanisms that distinguish p...

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Detalles Bibliográficos
Autores principales: Schinke, Carolina, Boyle, Eileen M., Ashby, Cody, Wang, Yan, Lyzogubov, Valeriy, Wardell, Christopher, Qu, Pingping, Hoering, Antje, Deshpande, Shayu, Ryan, Katie, Thanendrarajan, Sharmilan, Mohan, Meera, Yarlagadda, Naveen, Khan, Maliha, Choudhury, Samrat Roy, Zangari, Maurizio, van Rhee, Frits, Davies, Faith, Barlogie, Bart, Morgan, Gareth, Walker, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303180/
https://www.ncbi.nlm.nih.gov/pubmed/32555163
http://dx.doi.org/10.1038/s41408-020-0336-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303180/
https://www.ncbi.nlm.nih.gov/pubmed/32555163
http://dx.doi.org/10.1038/s41408-020-0336-z

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