Air contamination with SARS-CoV-2 in the operating room

Angiotensin converting enzyme 2 (ACE2) is a target cell receptor for internalization and proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). When ACE2-highly expressed tissues are manipulated, SARS-CoV-2 containing aerosols may be generated. Normal breathing and speaki...

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Autor principal: Hirota, Kazuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303274/
https://www.ncbi.nlm.nih.gov/pubmed/32562137
http://dx.doi.org/10.1007/s00540-020-02814-7
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author Hirota, Kazuyoshi
author_facet Hirota, Kazuyoshi
author_sort Hirota, Kazuyoshi
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description Angiotensin converting enzyme 2 (ACE2) is a target cell receptor for internalization and proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). When ACE2-highly expressed tissues are manipulated, SARS-CoV-2 containing aerosols may be generated. Normal breathing and speaking are capable of producing aerosols so mask ventilation, suction of airway tract and bucking during tracheal intubation and extubation are clinical procedures capable of significant aerosol production. Whilst no data have been reported on the distribution of SARS-CoV-2 in the operating room (OR), contamination in the OR can be estimated from the intensive care unit (ICU) data. ICU data showed that SARS-CoV-2 was detected on all types of surface and in air within about 4 m from coronavirus disease 2019 (COVID-19) patients. High concentrations of SARS-CoV-2 was detected in the personal protective equipment (PPE) removal room and medical staff office. Submicron virus-laden aerosols could result from resuspension of particles containing SARS-CoV-2 sticking the PPE surface; removal could produce the initial velocity. Supermicron virus-laden aerosol could come from floor deposited SARS-CoV-2, which were carried across different areas by medical staff (e.g., shoe). Knowledge of aerosol generation and distribution in the OR will aid the design of strategies to reduce transmission risk.
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spelling pubmed-73032742020-06-19 Air contamination with SARS-CoV-2 in the operating room Hirota, Kazuyoshi J Anesth Special Feature: Special Article Angiotensin converting enzyme 2 (ACE2) is a target cell receptor for internalization and proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). When ACE2-highly expressed tissues are manipulated, SARS-CoV-2 containing aerosols may be generated. Normal breathing and speaking are capable of producing aerosols so mask ventilation, suction of airway tract and bucking during tracheal intubation and extubation are clinical procedures capable of significant aerosol production. Whilst no data have been reported on the distribution of SARS-CoV-2 in the operating room (OR), contamination in the OR can be estimated from the intensive care unit (ICU) data. ICU data showed that SARS-CoV-2 was detected on all types of surface and in air within about 4 m from coronavirus disease 2019 (COVID-19) patients. High concentrations of SARS-CoV-2 was detected in the personal protective equipment (PPE) removal room and medical staff office. Submicron virus-laden aerosols could result from resuspension of particles containing SARS-CoV-2 sticking the PPE surface; removal could produce the initial velocity. Supermicron virus-laden aerosol could come from floor deposited SARS-CoV-2, which were carried across different areas by medical staff (e.g., shoe). Knowledge of aerosol generation and distribution in the OR will aid the design of strategies to reduce transmission risk. Springer Singapore 2020-06-19 2021 /pmc/articles/PMC7303274/ /pubmed/32562137 http://dx.doi.org/10.1007/s00540-020-02814-7 Text en © Japanese Society of Anesthesiologists 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Special Feature: Special Article
Hirota, Kazuyoshi
Air contamination with SARS-CoV-2 in the operating room
title Air contamination with SARS-CoV-2 in the operating room
title_full Air contamination with SARS-CoV-2 in the operating room
title_fullStr Air contamination with SARS-CoV-2 in the operating room
title_full_unstemmed Air contamination with SARS-CoV-2 in the operating room
title_short Air contamination with SARS-CoV-2 in the operating room
title_sort air contamination with sars-cov-2 in the operating room
topic Special Feature: Special Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303274/
https://www.ncbi.nlm.nih.gov/pubmed/32562137
http://dx.doi.org/10.1007/s00540-020-02814-7
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