Combined Treatment With 2-(2-Benzofu-Ranyl)-2-Imidazoline and Recombinant Tissue Plasminogen Activator Protects Blood–Brain Barrier Integrity in a Rat Model of Embolic Middle Cerebral Artery Occlusion

Recombinant tissue plasminogen activator (rt-PA) is used to treat acute ischemic stroke but is only effective if administered within 4.5 h after stroke onset. Delayed rt-PA treatment causes blood-brain barrier (BBB) disruption and hemorrhagic transformation. The compound 2-(-2-benzofuranyl)-2-imidaz...

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Detalles Bibliográficos
Autores principales: Zhang, Linlei, Xu, Shasha, Wu, Xiaoxiao, Chen, Jiaou, Guo, Xiaoling, Cao, Yungang, Zhang, Zheng, Yan, Jueyue, Cheng, Jianhua, Han, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303334/
https://www.ncbi.nlm.nih.gov/pubmed/32595494
http://dx.doi.org/10.3389/fphar.2020.00801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303334/
https://www.ncbi.nlm.nih.gov/pubmed/32595494
http://dx.doi.org/10.3389/fphar.2020.00801

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