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The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review

Osteoarthritis (OA) is a chronic joint disorder that causes degeneration of cartilage, synovial inflammation, and formation of osteophytes. Aging, obesity, and sex are considered the main risk factors of OA. Recent studies have suggested that metabolic syndrome (MetS) disorders, such as hypertension...

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Autores principales: Hashimoto, Kazuhiko, Akagi, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303502/
https://www.ncbi.nlm.nih.gov/pubmed/32552129
http://dx.doi.org/10.1177/0300060520931609
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author Hashimoto, Kazuhiko
Akagi, Masao
author_facet Hashimoto, Kazuhiko
Akagi, Masao
author_sort Hashimoto, Kazuhiko
collection PubMed
description Osteoarthritis (OA) is a chronic joint disorder that causes degeneration of cartilage, synovial inflammation, and formation of osteophytes. Aging, obesity, and sex are considered the main risk factors of OA. Recent studies have suggested that metabolic syndrome (MetS) disorders, such as hypertension, hyperlipidemia, diabetes mellitus, and obesity, may be involved in the pathogenesis and progression of OA. MetS disorders are common diseases that also result in atherosclerosis. Researchers believe that OA and atherosclerosis have underlying similar molecular mechanisms because the prevalence of both diseases increases with age. Oxidation of low-density lipoprotein (ox-LDL) is believed to play a role in the pathogenesis of atherosclerosis. Recent reports have shown that ox-LDL and low-density lipoprotein receptor 1 (LOX-1) are involved in the pathogenesis of OA. The purpose of this narrative review is to summarize the current understanding of the role of the LOX-1/ox-LDL system in the pathogenesis of OA and to reveal common underlying molecular pathways that are shared by MetS in OA and the LOX-1/ox-LDL system.
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spelling pubmed-73035022020-06-26 The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review Hashimoto, Kazuhiko Akagi, Masao J Int Med Res Review Osteoarthritis (OA) is a chronic joint disorder that causes degeneration of cartilage, synovial inflammation, and formation of osteophytes. Aging, obesity, and sex are considered the main risk factors of OA. Recent studies have suggested that metabolic syndrome (MetS) disorders, such as hypertension, hyperlipidemia, diabetes mellitus, and obesity, may be involved in the pathogenesis and progression of OA. MetS disorders are common diseases that also result in atherosclerosis. Researchers believe that OA and atherosclerosis have underlying similar molecular mechanisms because the prevalence of both diseases increases with age. Oxidation of low-density lipoprotein (ox-LDL) is believed to play a role in the pathogenesis of atherosclerosis. Recent reports have shown that ox-LDL and low-density lipoprotein receptor 1 (LOX-1) are involved in the pathogenesis of OA. The purpose of this narrative review is to summarize the current understanding of the role of the LOX-1/ox-LDL system in the pathogenesis of OA and to reveal common underlying molecular pathways that are shared by MetS in OA and the LOX-1/ox-LDL system. SAGE Publications 2020-06-18 /pmc/articles/PMC7303502/ /pubmed/32552129 http://dx.doi.org/10.1177/0300060520931609 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Hashimoto, Kazuhiko
Akagi, Masao
The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review
title The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review
title_full The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review
title_fullStr The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review
title_full_unstemmed The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review
title_short The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review
title_sort role of oxidation of low-density lipids in pathogenesis of osteoarthritis: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303502/
https://www.ncbi.nlm.nih.gov/pubmed/32552129
http://dx.doi.org/10.1177/0300060520931609
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