Fragment synthesis of disulfide-containing peptides

A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are: • Simple....

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Detalles Bibliográficos
Autores principales: Dai, Yuxuan, Yue, Na, Huang, Wenlong, Qian, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303597/
https://www.ncbi.nlm.nih.gov/pubmed/32577409
http://dx.doi.org/10.1016/j.mex.2020.100945
Descripción
Sumario:A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are: • Simple. • Low cost. • Solid phase based.

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