Fragment synthesis of disulfide-containing peptides

A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are: • Simple....

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Detalles Bibliográficos
Autores principales: Dai, Yuxuan, Yue, Na, Huang, Wenlong, Qian, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303597/
https://www.ncbi.nlm.nih.gov/pubmed/32577409
http://dx.doi.org/10.1016/j.mex.2020.100945
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author Dai, Yuxuan
Yue, Na
Huang, Wenlong
Qian, Hai
author_facet Dai, Yuxuan
Yue, Na
Huang, Wenlong
Qian, Hai
author_sort Dai, Yuxuan
collection PubMed
description A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are: • Simple. • Low cost. • Solid phase based.
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spelling pubmed-73035972020-06-22 Fragment synthesis of disulfide-containing peptides Dai, Yuxuan Yue, Na Huang, Wenlong Qian, Hai MethodsX Chemistry A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are: • Simple. • Low cost. • Solid phase based. Elsevier 2020-06-04 /pmc/articles/PMC7303597/ /pubmed/32577409 http://dx.doi.org/10.1016/j.mex.2020.100945 Text en © 2020 The Author(s). Published by Elsevier B.V. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Chemistry
Dai, Yuxuan
Yue, Na
Huang, Wenlong
Qian, Hai
Fragment synthesis of disulfide-containing peptides
title Fragment synthesis of disulfide-containing peptides
title_full Fragment synthesis of disulfide-containing peptides
title_fullStr Fragment synthesis of disulfide-containing peptides
title_full_unstemmed Fragment synthesis of disulfide-containing peptides
title_short Fragment synthesis of disulfide-containing peptides
title_sort fragment synthesis of disulfide-containing peptides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303597/
https://www.ncbi.nlm.nih.gov/pubmed/32577409
http://dx.doi.org/10.1016/j.mex.2020.100945
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AT yuena fragmentsynthesisofdisulfidecontainingpeptides
AT huangwenlong fragmentsynthesisofdisulfidecontainingpeptides
AT qianhai fragmentsynthesisofdisulfidecontainingpeptides

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