TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

Transforming growth factor beta-1 (TGF-β1) signaling is increased and mitochondrial function is decreased in multiple models of pulmonary hypertension (PH) including lambs with increased pulmonary blood flow (PBF) and pressure (Shunt). However, the potential link between TGF-β1 and the loss of mitoc...

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Detalles Bibliográficos
Autores principales: Sun, Xutong, Lu, Qing, Yegambaram, Manivannan, Kumar, Sanjiv, Qu, Ning, Srivastava, Anup, Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303661/
https://www.ncbi.nlm.nih.gov/pubmed/32554303
http://dx.doi.org/10.1016/j.redox.2020.101593

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