PNOC(ARC) Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding

Calorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice activates prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus of the hypothalamus (ARC). PNOC(ARC) neurons re...

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Detalles Bibliográficos
Autores principales: Jais, Alexander, Paeger, Lars, Sotelo-Hitschfeld, Tamara, Bremser, Stephan, Prinzensteiner, Melanie, Klemm, Paul, Mykytiuk, Vasyl, Widdershooven, Pia J.M., Vesting, Anna Juliane, Grzelka, Katarzyna, Minère, Marielle, Cremer, Anna Lena, Xu, Jie, Korotkova, Tatiana, Lowell, Bradford B., Zeilhofer, Hanns Ulrich, Backes, Heiko, Fenselau, Henning, Wunderlich, F. Thomas, Kloppenburg, Peter, Brüning, Jens C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303947/
https://www.ncbi.nlm.nih.gov/pubmed/32302532
http://dx.doi.org/10.1016/j.neuron.2020.03.022

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