Cargando…
The Roles of Glycans in Bladder Cancer
Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303958/ https://www.ncbi.nlm.nih.gov/pubmed/32596162 http://dx.doi.org/10.3389/fonc.2020.00957 |
_version_ | 1783548167445282816 |
---|---|
author | Jian, Yuli Xu, Zhongyang Xu, Chunyan Zhang, Lin Sun, Xiaoxin Yang, Deyong Wang, Shujing |
author_facet | Jian, Yuli Xu, Zhongyang Xu, Chunyan Zhang, Lin Sun, Xiaoxin Yang, Deyong Wang, Shujing |
author_sort | Jian, Yuli |
collection | PubMed |
description | Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent to find suitable therapeutic targets and biomarkers. Glycans are one of the four biological macromolecules in the cells of an organism, along with proteins, nucleic acids, and lipids. Glycans play important roles in nascent peptide chain folding, protein processing, and translation, cell-to-cell adhesion, receptor-ligand recognition, and binding and cell signaling. Glycans are mainly divided into N-glycans, O-glycans, proteoglycans, and glycosphingolipids. The focus of this review is the discussion of glycans related to bladder cancer. Additionally, this review also addresses the clinical value of glycans in the diagnosis and treatment of bladder cancer. Abnormal glycans are likely to be potential biomarkers for bladder cancer. |
format | Online Article Text |
id | pubmed-7303958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73039582020-06-26 The Roles of Glycans in Bladder Cancer Jian, Yuli Xu, Zhongyang Xu, Chunyan Zhang, Lin Sun, Xiaoxin Yang, Deyong Wang, Shujing Front Oncol Oncology Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent to find suitable therapeutic targets and biomarkers. Glycans are one of the four biological macromolecules in the cells of an organism, along with proteins, nucleic acids, and lipids. Glycans play important roles in nascent peptide chain folding, protein processing, and translation, cell-to-cell adhesion, receptor-ligand recognition, and binding and cell signaling. Glycans are mainly divided into N-glycans, O-glycans, proteoglycans, and glycosphingolipids. The focus of this review is the discussion of glycans related to bladder cancer. Additionally, this review also addresses the clinical value of glycans in the diagnosis and treatment of bladder cancer. Abnormal glycans are likely to be potential biomarkers for bladder cancer. Frontiers Media S.A. 2020-06-12 /pmc/articles/PMC7303958/ /pubmed/32596162 http://dx.doi.org/10.3389/fonc.2020.00957 Text en Copyright © 2020 Jian, Xu, Xu, Zhang, Sun, Yang and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Jian, Yuli Xu, Zhongyang Xu, Chunyan Zhang, Lin Sun, Xiaoxin Yang, Deyong Wang, Shujing The Roles of Glycans in Bladder Cancer |
title | The Roles of Glycans in Bladder Cancer |
title_full | The Roles of Glycans in Bladder Cancer |
title_fullStr | The Roles of Glycans in Bladder Cancer |
title_full_unstemmed | The Roles of Glycans in Bladder Cancer |
title_short | The Roles of Glycans in Bladder Cancer |
title_sort | roles of glycans in bladder cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303958/ https://www.ncbi.nlm.nih.gov/pubmed/32596162 http://dx.doi.org/10.3389/fonc.2020.00957 |
work_keys_str_mv | AT jianyuli therolesofglycansinbladdercancer AT xuzhongyang therolesofglycansinbladdercancer AT xuchunyan therolesofglycansinbladdercancer AT zhanglin therolesofglycansinbladdercancer AT sunxiaoxin therolesofglycansinbladdercancer AT yangdeyong therolesofglycansinbladdercancer AT wangshujing therolesofglycansinbladdercancer AT jianyuli rolesofglycansinbladdercancer AT xuzhongyang rolesofglycansinbladdercancer AT xuchunyan rolesofglycansinbladdercancer AT zhanglin rolesofglycansinbladdercancer AT sunxiaoxin rolesofglycansinbladdercancer AT yangdeyong rolesofglycansinbladdercancer AT wangshujing rolesofglycansinbladdercancer |