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Correlations of morphology and molecular alterations in traditional serrated adenoma
Traditional serrated adenoma was first reported by Longacre and Fenoglio-Presier in 1990. Their initial study described main features of this lesion, but the consensus diagnostic criteria were not widely adopted until recently. Traditional serrated adenoma presents with grossly protuberant configura...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303981/ https://www.ncbi.nlm.nih.gov/pubmed/32587787 http://dx.doi.org/10.4291/wjgp.v11.i4.78 |
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author | Gui, Hongxing Husson, Michael A Mannan, Rifat |
author_facet | Gui, Hongxing Husson, Michael A Mannan, Rifat |
author_sort | Gui, Hongxing |
collection | PubMed |
description | Traditional serrated adenoma was first reported by Longacre and Fenoglio-Presier in 1990. Their initial study described main features of this lesion, but the consensus diagnostic criteria were not widely adopted until recently. Traditional serrated adenoma presents with grossly protuberant configuration and pinecone-like appearance upon endoscopy. Histologically, it is characterized by ectopic crypt formation, slit-like serration, eosinophilic cytoplasm and pencillate nuclei. Although much is now known about the morphology and molecular changes, the mechanisms underlying the morphological alterations are still not fully understood. Furthermore, the origin of traditional serrated adenoma is not completely known. We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity. |
format | Online Article Text |
id | pubmed-7303981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-73039812020-06-24 Correlations of morphology and molecular alterations in traditional serrated adenoma Gui, Hongxing Husson, Michael A Mannan, Rifat World J Gastrointest Pathophysiol Minireviews Traditional serrated adenoma was first reported by Longacre and Fenoglio-Presier in 1990. Their initial study described main features of this lesion, but the consensus diagnostic criteria were not widely adopted until recently. Traditional serrated adenoma presents with grossly protuberant configuration and pinecone-like appearance upon endoscopy. Histologically, it is characterized by ectopic crypt formation, slit-like serration, eosinophilic cytoplasm and pencillate nuclei. Although much is now known about the morphology and molecular changes, the mechanisms underlying the morphological alterations are still not fully understood. Furthermore, the origin of traditional serrated adenoma is not completely known. We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity. Baishideng Publishing Group Inc 2020-06-20 2020-06-20 /pmc/articles/PMC7303981/ /pubmed/32587787 http://dx.doi.org/10.4291/wjgp.v11.i4.78 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Gui, Hongxing Husson, Michael A Mannan, Rifat Correlations of morphology and molecular alterations in traditional serrated adenoma |
title | Correlations of morphology and molecular alterations in traditional serrated adenoma |
title_full | Correlations of morphology and molecular alterations in traditional serrated adenoma |
title_fullStr | Correlations of morphology and molecular alterations in traditional serrated adenoma |
title_full_unstemmed | Correlations of morphology and molecular alterations in traditional serrated adenoma |
title_short | Correlations of morphology and molecular alterations in traditional serrated adenoma |
title_sort | correlations of morphology and molecular alterations in traditional serrated adenoma |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303981/ https://www.ncbi.nlm.nih.gov/pubmed/32587787 http://dx.doi.org/10.4291/wjgp.v11.i4.78 |
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