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Correlations of morphology and molecular alterations in traditional serrated adenoma

Traditional serrated adenoma was first reported by Longacre and Fenoglio-Presier in 1990. Their initial study described main features of this lesion, but the consensus diagnostic criteria were not widely adopted until recently. Traditional serrated adenoma presents with grossly protuberant configura...

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Autores principales: Gui, Hongxing, Husson, Michael A, Mannan, Rifat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303981/
https://www.ncbi.nlm.nih.gov/pubmed/32587787
http://dx.doi.org/10.4291/wjgp.v11.i4.78
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author Gui, Hongxing
Husson, Michael A
Mannan, Rifat
author_facet Gui, Hongxing
Husson, Michael A
Mannan, Rifat
author_sort Gui, Hongxing
collection PubMed
description Traditional serrated adenoma was first reported by Longacre and Fenoglio-Presier in 1990. Their initial study described main features of this lesion, but the consensus diagnostic criteria were not widely adopted until recently. Traditional serrated adenoma presents with grossly protuberant configuration and pinecone-like appearance upon endoscopy. Histologically, it is characterized by ectopic crypt formation, slit-like serration, eosinophilic cytoplasm and pencillate nuclei. Although much is now known about the morphology and molecular changes, the mechanisms underlying the morphological alterations are still not fully understood. Furthermore, the origin of traditional serrated adenoma is not completely known. We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity.
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spelling pubmed-73039812020-06-24 Correlations of morphology and molecular alterations in traditional serrated adenoma Gui, Hongxing Husson, Michael A Mannan, Rifat World J Gastrointest Pathophysiol Minireviews Traditional serrated adenoma was first reported by Longacre and Fenoglio-Presier in 1990. Their initial study described main features of this lesion, but the consensus diagnostic criteria were not widely adopted until recently. Traditional serrated adenoma presents with grossly protuberant configuration and pinecone-like appearance upon endoscopy. Histologically, it is characterized by ectopic crypt formation, slit-like serration, eosinophilic cytoplasm and pencillate nuclei. Although much is now known about the morphology and molecular changes, the mechanisms underlying the morphological alterations are still not fully understood. Furthermore, the origin of traditional serrated adenoma is not completely known. We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity. Baishideng Publishing Group Inc 2020-06-20 2020-06-20 /pmc/articles/PMC7303981/ /pubmed/32587787 http://dx.doi.org/10.4291/wjgp.v11.i4.78 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Gui, Hongxing
Husson, Michael A
Mannan, Rifat
Correlations of morphology and molecular alterations in traditional serrated adenoma
title Correlations of morphology and molecular alterations in traditional serrated adenoma
title_full Correlations of morphology and molecular alterations in traditional serrated adenoma
title_fullStr Correlations of morphology and molecular alterations in traditional serrated adenoma
title_full_unstemmed Correlations of morphology and molecular alterations in traditional serrated adenoma
title_short Correlations of morphology and molecular alterations in traditional serrated adenoma
title_sort correlations of morphology and molecular alterations in traditional serrated adenoma
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303981/
https://www.ncbi.nlm.nih.gov/pubmed/32587787
http://dx.doi.org/10.4291/wjgp.v11.i4.78
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