A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis

A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and...

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Autores principales: Takahara, Yutaka, Yamamura, Kouichi, Matsuura, Saki, Sakuma, Takashi, Nishiki, Kazuaki, Nakase, Keisuke, Nojiri, Masafumi, Kato, Ryo, Shinomiya, Shohei, Oikawa, Rieko, Fujimoto, Yuki, Oikawa, Taku, Osanai, Kazuhiro, Ueda, Yoshimichi, Mizuno, Shiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303991/
https://www.ncbi.nlm.nih.gov/pubmed/32577365
http://dx.doi.org/10.1016/j.rmcr.2020.101124
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author Takahara, Yutaka
Yamamura, Kouichi
Matsuura, Saki
Sakuma, Takashi
Nishiki, Kazuaki
Nakase, Keisuke
Nojiri, Masafumi
Kato, Ryo
Shinomiya, Shohei
Oikawa, Rieko
Fujimoto, Yuki
Oikawa, Taku
Osanai, Kazuhiro
Ueda, Yoshimichi
Mizuno, Shiro
author_facet Takahara, Yutaka
Yamamura, Kouichi
Matsuura, Saki
Sakuma, Takashi
Nishiki, Kazuaki
Nakase, Keisuke
Nojiri, Masafumi
Kato, Ryo
Shinomiya, Shohei
Oikawa, Rieko
Fujimoto, Yuki
Oikawa, Taku
Osanai, Kazuhiro
Ueda, Yoshimichi
Mizuno, Shiro
author_sort Takahara, Yutaka
collection PubMed
description A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer.
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spelling pubmed-73039912020-06-22 A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis Takahara, Yutaka Yamamura, Kouichi Matsuura, Saki Sakuma, Takashi Nishiki, Kazuaki Nakase, Keisuke Nojiri, Masafumi Kato, Ryo Shinomiya, Shohei Oikawa, Rieko Fujimoto, Yuki Oikawa, Taku Osanai, Kazuhiro Ueda, Yoshimichi Mizuno, Shiro Respir Med Case Rep Case Report A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer. Elsevier 2020-06-12 /pmc/articles/PMC7303991/ /pubmed/32577365 http://dx.doi.org/10.1016/j.rmcr.2020.101124 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takahara, Yutaka
Yamamura, Kouichi
Matsuura, Saki
Sakuma, Takashi
Nishiki, Kazuaki
Nakase, Keisuke
Nojiri, Masafumi
Kato, Ryo
Shinomiya, Shohei
Oikawa, Rieko
Fujimoto, Yuki
Oikawa, Taku
Osanai, Kazuhiro
Ueda, Yoshimichi
Mizuno, Shiro
A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
title A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
title_full A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
title_fullStr A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
title_full_unstemmed A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
title_short A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
title_sort case of ros1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303991/
https://www.ncbi.nlm.nih.gov/pubmed/32577365
http://dx.doi.org/10.1016/j.rmcr.2020.101124
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