MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population

BACKGROUND: Liver cancer is one of the most common cancers in the world. The primary aim of this research was to discover the correlation between single nucleotide polymorphisms (SNPs) of the MIR155HG and liver cancer risk. METHODS: The selected SNPs in MIR155HG were genotyped utilizing the Agena Ma...

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Autores principales: Chao, Xu, Feng, Xuesong, Wang, Xiaoping, Shi, Hailong, Li, Hong, Wang, Yuewen, Wang, Lanlan, Shen, Haiyu, Zha, Qing, Chen, Yanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304092/
https://www.ncbi.nlm.nih.gov/pubmed/32560637
http://dx.doi.org/10.1186/s12881-020-01064-4
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author Chao, Xu
Feng, Xuesong
Wang, Xiaoping
Shi, Hailong
Li, Hong
Wang, Yuewen
Wang, Lanlan
Shen, Haiyu
Zha, Qing
Chen, Yanni
author_facet Chao, Xu
Feng, Xuesong
Wang, Xiaoping
Shi, Hailong
Li, Hong
Wang, Yuewen
Wang, Lanlan
Shen, Haiyu
Zha, Qing
Chen, Yanni
author_sort Chao, Xu
collection PubMed
description BACKGROUND: Liver cancer is one of the most common cancers in the world. The primary aim of this research was to discover the correlation between single nucleotide polymorphisms (SNPs) of the MIR155HG and liver cancer risk. METHODS: The selected SNPs in MIR155HG were genotyped utilizing the Agena MassARRAY platform. We evaluated the correlation between MIR155HG polymorphisms and Liver cancer by genetic model analysis, stratification analysis and haplotype analysis. Relative risk of Liver cancer was shown based on odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Our results uncovered that rs12482371 and rs1893650 in the MIR155HG were associated with protection against Liver cancer. And the rs928883 was related to increase risk of Liver cancer. Furthermore, apart from rs77218221, other selected SNPs formed two LD blocks, and haplotype “GATAG” in block 2 elevated individual liver cancer risk. CONCLUSIONS: MIR155HG gene polymorphism may be correlated to Liver cancer susceptibility in Han Chinese population, particularly in males and aged ≤55 years.
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spelling pubmed-73040922020-06-22 MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population Chao, Xu Feng, Xuesong Wang, Xiaoping Shi, Hailong Li, Hong Wang, Yuewen Wang, Lanlan Shen, Haiyu Zha, Qing Chen, Yanni BMC Med Genet Research Article BACKGROUND: Liver cancer is one of the most common cancers in the world. The primary aim of this research was to discover the correlation between single nucleotide polymorphisms (SNPs) of the MIR155HG and liver cancer risk. METHODS: The selected SNPs in MIR155HG were genotyped utilizing the Agena MassARRAY platform. We evaluated the correlation between MIR155HG polymorphisms and Liver cancer by genetic model analysis, stratification analysis and haplotype analysis. Relative risk of Liver cancer was shown based on odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Our results uncovered that rs12482371 and rs1893650 in the MIR155HG were associated with protection against Liver cancer. And the rs928883 was related to increase risk of Liver cancer. Furthermore, apart from rs77218221, other selected SNPs formed two LD blocks, and haplotype “GATAG” in block 2 elevated individual liver cancer risk. CONCLUSIONS: MIR155HG gene polymorphism may be correlated to Liver cancer susceptibility in Han Chinese population, particularly in males and aged ≤55 years. BioMed Central 2020-06-19 /pmc/articles/PMC7304092/ /pubmed/32560637 http://dx.doi.org/10.1186/s12881-020-01064-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Chao, Xu
Feng, Xuesong
Wang, Xiaoping
Shi, Hailong
Li, Hong
Wang, Yuewen
Wang, Lanlan
Shen, Haiyu
Zha, Qing
Chen, Yanni
MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population
title MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population
title_full MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population
title_fullStr MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population
title_full_unstemmed MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population
title_short MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population
title_sort mirna155hg polymorphisms influenced the risk of liver cancer among the han chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304092/
https://www.ncbi.nlm.nih.gov/pubmed/32560637
http://dx.doi.org/10.1186/s12881-020-01064-4
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