Cargando…

Nutrition in alcohol-related liver disease: Physiopathology and management

Malnutrition encompassing both macro- and micro-nutrient deficiency, remains one of the most frequent complications of alcohol-related liver disease (ArLD). Protein-energy malnutrition can cause significant complications including sarcopenia, frailty and immunodepression in cirrhotic patients. Malnu...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamran, Umair, Towey, Jennifer, Khanna, Amardeep, Chauhan, Abhishek, Rajoriya, Neil, Holt, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304106/
https://www.ncbi.nlm.nih.gov/pubmed/32587439
http://dx.doi.org/10.3748/wjg.v26.i22.2916
_version_ 1783548199072432128
author Kamran, Umair
Towey, Jennifer
Khanna, Amardeep
Chauhan, Abhishek
Rajoriya, Neil
Holt, Andrew
author_facet Kamran, Umair
Towey, Jennifer
Khanna, Amardeep
Chauhan, Abhishek
Rajoriya, Neil
Holt, Andrew
author_sort Kamran, Umair
collection PubMed
description Malnutrition encompassing both macro- and micro-nutrient deficiency, remains one of the most frequent complications of alcohol-related liver disease (ArLD). Protein-energy malnutrition can cause significant complications including sarcopenia, frailty and immunodepression in cirrhotic patients. Malnutrition reduces patient’s survival and negatively affects the quality of life of individuals with ArLD. Moreover, nutritional deficit increases the likelihood of hepatic decompensation in cirrhosis. Prompt recognition of at-risk individuals, early diagnosis and treatment of malnutrition remains a key component of ArLD management. In this review, we describe the pathophysiology of malnutrition in ArLD, review the screening tools available for nutritional assessment and discuss nutritional management strategies relevant to the different stages of ArLD, ranging from acute alcoholic hepatitis through to decompensated end stage liver disease.
format Online
Article
Text
id pubmed-7304106
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-73041062020-06-24 Nutrition in alcohol-related liver disease: Physiopathology and management Kamran, Umair Towey, Jennifer Khanna, Amardeep Chauhan, Abhishek Rajoriya, Neil Holt, Andrew World J Gastroenterol Review Malnutrition encompassing both macro- and micro-nutrient deficiency, remains one of the most frequent complications of alcohol-related liver disease (ArLD). Protein-energy malnutrition can cause significant complications including sarcopenia, frailty and immunodepression in cirrhotic patients. Malnutrition reduces patient’s survival and negatively affects the quality of life of individuals with ArLD. Moreover, nutritional deficit increases the likelihood of hepatic decompensation in cirrhosis. Prompt recognition of at-risk individuals, early diagnosis and treatment of malnutrition remains a key component of ArLD management. In this review, we describe the pathophysiology of malnutrition in ArLD, review the screening tools available for nutritional assessment and discuss nutritional management strategies relevant to the different stages of ArLD, ranging from acute alcoholic hepatitis through to decompensated end stage liver disease. Baishideng Publishing Group Inc 2020-06-14 2020-06-14 /pmc/articles/PMC7304106/ /pubmed/32587439 http://dx.doi.org/10.3748/wjg.v26.i22.2916 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Kamran, Umair
Towey, Jennifer
Khanna, Amardeep
Chauhan, Abhishek
Rajoriya, Neil
Holt, Andrew
Nutrition in alcohol-related liver disease: Physiopathology and management
title Nutrition in alcohol-related liver disease: Physiopathology and management
title_full Nutrition in alcohol-related liver disease: Physiopathology and management
title_fullStr Nutrition in alcohol-related liver disease: Physiopathology and management
title_full_unstemmed Nutrition in alcohol-related liver disease: Physiopathology and management
title_short Nutrition in alcohol-related liver disease: Physiopathology and management
title_sort nutrition in alcohol-related liver disease: physiopathology and management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304106/
https://www.ncbi.nlm.nih.gov/pubmed/32587439
http://dx.doi.org/10.3748/wjg.v26.i22.2916
work_keys_str_mv AT kamranumair nutritioninalcoholrelatedliverdiseasephysiopathologyandmanagement
AT toweyjennifer nutritioninalcoholrelatedliverdiseasephysiopathologyandmanagement
AT khannaamardeep nutritioninalcoholrelatedliverdiseasephysiopathologyandmanagement
AT chauhanabhishek nutritioninalcoholrelatedliverdiseasephysiopathologyandmanagement
AT rajoriyaneil nutritioninalcoholrelatedliverdiseasephysiopathologyandmanagement
AT holtandrew nutritioninalcoholrelatedliverdiseasephysiopathologyandmanagement