Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology

BACKGROUND: The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear. METHODS: This is a prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6 mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. RESULTS: Visual acuity and refraction improved significantly after OK lens wear. △ETFm thinned more than △ETSm (P = 0.027) at 1.5 mm in radius. △ETSm thickened more than △ETFm at 2.5 mm (P = 0.019) and 3.0 mm (P = 0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0 mm, 2.5 mm and 3.0 mm. ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5 mm. CONCLUSIONS: Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.