Cargando…
A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease
One of remarkable features of sporadic Creutzfeldt-Jakob disease (sCJD) is the great phenotypic variability. Understanding the molecular basis of this variability has important implications for the development of therapeutic approaches. It is well established that, in many cases, phenotypic heteroge...
Autores principales: | Nemani, Satish K., Xiao, Xiangzhu, Cali, Ignazio, Cracco, Laura, Puoti, Gianfranco, Nigro, Massimiliano, Lavrich, Jody, Bharara Singh, Anuradha, Appleby, Brian S., Sim, Valerie L., Notari, Silvio, Surewicz, Witold K., Gambetti, Pierluigi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304206/ https://www.ncbi.nlm.nih.gov/pubmed/32560672 http://dx.doi.org/10.1186/s40478-020-00966-x |
Ejemplares similares
-
Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments
por: Cracco, Laura, et al.
Publicado: (2019) -
Co-existence of PrP(D) types 1 and 2 in sporadic Creutzfeldt-Jakob disease of the VV subgroup: phenotypic and prion protein characteristics
por: Cali, Ignazio, et al.
Publicado: (2020) -
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
por: Cracco, Laura, et al.
Publicado: (2023) -
PMCA-replicated PrP(D) in urine of vCJD patients maintains infectivity and strain characteristics of brain PrP(D): Transmission study
por: Cali, Ignazio, et al.
Publicado: (2019) -
Two distinct conformers of PrP(D) type 1 of sporadic Creutzfeldt–Jakob disease with codon 129VV genotype faithfully propagate in vivo
por: Cali, Ignazio, et al.
Publicado: (2021)