Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

BACKGROUND: Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder. Notwithstanding the extensive studies using rodent and other pre-clinical models of FXS, which have provided detailed mechanistic insights into...

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Detalles Bibliográficos
Autores principales: Das Sharma, Shreya, Pal, Rakhi, Reddy, Bharath Kumar, Selvaraj, Bhuvaneish T., Raj, Nisha, Samaga, Krishna Kumar, Srinivasan, Durga J., Ornelas, Loren, Sareen, Dhruv, Livesey, Matthew R., Bassell, Gary J., Svendsen, Clive N., Kind, Peter C., Chandran, Siddharthan, Chattarji, Sumantra, Wyllie, David J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304215/
https://www.ncbi.nlm.nih.gov/pubmed/32560741
http://dx.doi.org/10.1186/s13229-020-00351-4

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